A Japanese Case of COVID-19 Caused by Omicron Strain with Y453F Substitution.

Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology Pub Date : 2023-12-26

Hiroka Yamazaki, Yasunori Iwata, Akiko Maekawa, Tomoko Azuma, Yui Shimano, Tadafumi Yokoyama, Junya Nakade, Yasunari Tanaka, Yoko Nakamura, Yoshinori Takahashi, Yoshitaka Zaimoku, Hiroyasu Oe, Megumi Oshima, Mika Mori, Toshifumi Gabata

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Abstract

Frequent mutations of SARS-CoV-2 change the strain more transmissible, leading to the pandemic in worldwide. We detected Y453F substitution on Omicron strain, isolated from a Japanese patient in July 2022. While Y453F substitution was identified B1.1.298 lineage in Netherlands and Denmark in 2020, the substitution has not been reported in Omicron strain especially in Japan. Y453F substitution is associated with higher viral infectivity because it is sited in the receptor-binding domain (RBD), and Y453F substitution contributes to increase binding affinity to angiotensin converting enzyme 2 (ACE2). Additionally, Y453F substitution has been reported to escape human leukocyte antigen (HLA), which is known to recognize non-self-antigens in virus-infected cells as cellular immunity, so it should be closely monitored.

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日本一例由含有 Y453F 替代物的 Omicron 菌株引起的 COVID-19 病例。

SARS-CoV-2病毒的频繁变异使该病毒株的传播性更强，导致了该病毒在全球的大流行。我们在 2022 年 7 月从一名日本患者身上分离出的 Omicron 株上发现了 Y453F 突变。虽然 2020 年在荷兰和丹麦的 B1.1.298 株系中发现了 Y453F 置换，但在 Omicron 株系中，尤其是在日本，尚未发现这种置换。Y453F 置换与病毒的高感染性有关，因为它位于受体结合域（RBD），Y453F 置换有助于增加与血管紧张素转换酶 2（ACE2）的结合亲和力。此外，有报道称 Y453F 取代可逃避人类白细胞抗原（HLA），而 HLA 可识别病毒感染细胞中的非自身抗原作为细胞免疫，因此应密切监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology

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