Review on advancements of pyranopyrazole: synthetic routes and their medicinal applications.

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED Molecular Diversity Pub Date : 2024-10-01 Epub Date: 2024-01-18 DOI:10.1007/s11030-023-10757-w

Ashok R Yadav, Ashishkumar P Katariya, Anant B Kanagare, Pramod D Jawale Patil, Chandrakant K Tagad, Satish A Dake, Pratik A Nagwade, Satish U Deshmukh

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Abstract

Pyranopyrazoles are among the most distinguished, biologically potent, and exciting scaffolds in medicinal chemistry and drug discovery. Synthesis and design of pyranopyrazoles using functional modifications via multicomponent reactions (MCRs) are thoroughly found in synthetic protocols by forming new C-C, C-N, and C-O bonds. This review aims to focus on the biological importance of pyranopyrazoles as well as on a diverse synthetic approach for their synthesis using various catalytic systems such as acid-catalyzed, base-catalyzed, ionic liquids and green media-catalyzed, nano-particle-catalyzed, metal oxide-supported catalysts, and silica-supported catalysts. In this review, we have summarized data on the advancements in synthesizing pyranopyrazole from the last two decades to the mid-2023 and research papers describing the importance of these scaffolds. This review will be significant for synthetic organic chemists and researchers working in organic chemistry.

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综述吡喃吡唑的研究进展：合成路线及其药物应用。

吡喃吡唑是药物化学和药物发现领域中最杰出、最具生物效力和最令人兴奋的支架之一。通过多组分反应（MCR）进行功能修饰，形成新的 C-C、C-N 和 C-O 键，从而合成和设计吡喃并唑的方法在合成方案中被广泛采用。本综述旨在关注吡喃吡唑的生物学重要性，以及利用各种催化体系（如酸催化、碱催化、离子液体和绿色介质催化、纳米粒子催化、金属氧化物支撑催化剂和二氧化硅支撑催化剂）合成吡喃吡唑的多样化合成方法。在本综述中，我们总结了从过去二十年到 2023 年中期合成吡喃吡唑的进展数据，以及描述这些支架重要性的研究论文。本综述对从事有机化学研究的合成有机化学家和研究人员具有重要意义。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;