Evaluation of corneal endothelial cell morphology off and on treatment by specular microscopy in children and adolescents with attention deficit hyperactivity disorder.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-06-01 Epub Date: 2024-01-18 DOI:10.1080/15569527.2024.2303442
Hakan Koc, Bedia Sultan Önal, Esra Hoşoğlu
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Abstract

Purpose: To determine the structure and properties of corneal endothelial cells in children and adolescents with ADHD who received methylphenidate treatment at least six months.

Method: The prospective, observational study included 33 eyes of 33 patients diagnosed with ADHD who received methylphenidate treatment for at least six months, 33 eyes of 33 patients newly diagnosed with ADHD who did not start medication treatment, and 33 eyes of 33 healthy individuals. Average cell density, coefficient of variation, maximum cell area, normal cell area, minimum cell area, average cell area, and hexagonality ratio values were evaluated by non-contact specular microscopy. The parameters recorded in all three groups were compared.

Results: The average age of children in the ADHD + MPH, ADHD, and control groups is 9 ± 1.7, 8.9 ± 2.3, and 8.9 ± 1.8 years, respectively. (p > 0.05) The average MPH treatment dose is 0.94 ± 0.19 mg/kg, the average daily MPH intake is 34.12 ± 14.04 mg, and the average duration of use of MPH is 24.03 ± 12.46 months. Central corneal thickness (CCT) was measured as an average of 540.45 ± 31.23 in the ADHD + MPH group, 540.61 ± 29.69 in the ADHD group, and 546.58 ± 27.72 in the control group. (p = 0.499) The average coefficient of variation (CV) values were measured as 25.48 ± 4.22 in the ADHD + MPH group, 26.12 ± 3.48 in the ADHD group, and 26.12 ± 3.64 in the control group. (p = 0.491) The average hexagonality ratio (%) (HEX) values were measured as 69.45 ± 8.41 in the ADHD + MPH group, 68.21 ± 6.82 in the ADHD group, and 68.91 ± 7.97 in the control group. (p = 0.892) No statistically significant difference was observed between all three groups in terms of all parameters.

Conclusion: Methylphenidate treatment administered for at least six months with a diagnosis of ADHD did not have a toxic effect on the corneal endothelium.

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通过镜检显微镜评估患有注意力缺陷多动障碍的儿童和青少年在治疗期间和治疗后的角膜内皮细胞形态。
目的:确定接受哌醋甲酯治疗至少六个月的多动症儿童和青少年角膜内皮细胞的结构和特性:这项前瞻性观察研究包括 33 名接受哌醋甲酯治疗至少 6 个月的多动症患者的 33 只眼睛、33 名新诊断为多动症但未开始接受药物治疗的患者的 33 只眼睛以及 33 名健康人的 33 只眼睛。通过非接触式镜面显微镜评估了平均细胞密度、变异系数、最大细胞面积、正常细胞面积、最小细胞面积、平均细胞面积和六边形比率值。对三组记录的参数进行了比较:ADHD+MPH组、ADHD组和对照组儿童的平均年龄分别为(9 ± 1.7)岁、(8.9 ± 2.3)岁和(8.9 ± 1.8)岁。(P>0.05)MPH的平均治疗剂量为0.94±0.19毫克/千克,MPH的平均日摄入量为34.12±14.04毫克,MPH的平均使用时间为24.03±12.46个月。经测量,ADHD + MPH 组的中央角膜厚度(CCT)平均为(540.45 ± 31.23),ADHD 组为(540.61 ± 29.69),对照组为(546.58 ± 27.72)。(p = 0.499) ADHD + MPH 组的平均变异系数 (CV) 值为 25.48 ± 4.22,ADHD 组为 26.12 ± 3.48,对照组为 26.12 ± 3.64。(p = 0.491) ADHD + MPH 组的平均六方比率(%)(HEX)值为(69.45 ± 8.41),ADHD 组为(68.21 ± 6.82),对照组为(68.91 ± 7.97)。(p = 0.892)在所有参数方面,三组之间均未观察到明显的统计学差异:结论:被诊断为多动症的患者接受至少六个月的哌醋甲酯治疗不会对角膜内皮产生毒性影响。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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