Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome.

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-01-18 DOI:10.1080/09513590.2023.2301554
Iñaki Lete, Ainara Martínez, Irene Lasaga, Eva Centurión, Amaia Vesga
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Abstract

In this article, we present a narrative review on the use of inositol in the treatment of polycystic ovary syndrome (PCOS). Of the different inositols that exist, only myo-inositol (MYO) and D-chiro inositol (DCI) have been studied in the treatment of PCOS. The results of the studies show that there is insufficient or controversial evidence to recommend the use of DCI alone, while MYO alone shows positive results and, above all, the MYO/DCI combination is effective when used at a ratio of at least 40:1, but there is enough rationale to further study ratios such as 66:1 to 100:1 as other possible effective combinations.

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肌醇/二千-肌醇联合疗法治疗多囊卵巢综合征的最新进展。
在本文中,我们对肌醇在治疗多囊卵巢综合症(PCOS)中的应用进行了叙述性综述。在现有的各种肌醇中,只有肌醇(MYO)和D-肌醇(DCI)被研究用于治疗多囊卵巢综合症。研究结果表明,建议单独使用 DCI 的证据不足或存在争议,而单独使用 MYO 则显示出积极的效果,最重要的是,MYO/DCI 组合在以至少 40:1 的比例使用时是有效的,但有足够的理由进一步研究 66:1 至 100:1 等其他可能的有效组合比例。
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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
期刊最新文献
Statement of Retraction: Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial. Statement of Retraction: Minimal stimulation or clomiphene citrate as first-line therapy in women with polycystic ovary syndrome: a randomized controlled trial. Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3. Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome. Comparative effects of the antioxidant glutathione with metformin and Diane-35 on hormonal, metabolic, and inflammatory indicators in a DHEA-induced PCOS rat model.
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