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MiR-19b-3p inhibits cell viability and proliferation and promotes apoptosis by targeting IGF1 in KGN cells. MiR-19b-3p 通过靶向 IGF1 抑制 KGN 细胞的活力和增殖,并促进细胞凋亡。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1080/09513590.2024.2425318
Youzhu Li, Yuanyuan Ye, Hengyuan Zhang, Ye Yang, Ningqing Zhang, Hong Gao, Rongfeng Wu

Background: Endometriosis (EM) is a major cause of infertility, but the pathogenesis and mechanisms are not yet fully elucidated. MiR-19b-3p is involved in many diseases, but its functional role in EM-associated infertility remains unexplored. This study aimed to examine miR-19b-3p abundance and IGF1 concentration in cumulus cells (CCs) and follicular fluid of EM-associated infertility patients, and to investigate the potential role of miR-19b-3p in KGN cells by identifying its target and elucidating the underlying mechanisms.

Results: The results from the case-control study indicated that, compared to the control group consisting of patients with tubal infertility, patients with EM-associated infertility exhibited a lower percentage of mature oocytes. MiR-19b-3p level was elevated in CCs from EM-associated infertility patients. IGF1 was identified as a direct target of miR-19b-3p and was negatively regulated by miR-19b-3p in KGN cells. Overexpression of miR-19b-3p significantly inhibited cell viability and proliferation, promoted apoptosis, and arrested the cell cycle at G0/G1 phase in KGN cells. The effects of miR-19b-3p were reversed by co-transfection of IGF1, and the biological effects of miR-19b-3p in KGN cells were mediated by IGF1. Additionally, miR-19b-3p targeted IGF1 to down-regulate AKT phosphorylation and participate in the apoptotic pathway in KGN cells.

Conclusions: This study demonstrates that miR-19b-3p level is elevated in CCs and IGF1 concentration is decreased in follicular fluid in patients with EM-associated infertility. MiR-19b-3p regulates the biological effects of KGN cells by targeting IGF1.

背景:子宫内膜异位症(EM)是导致不孕的主要原因之一,但其发病机制尚未完全阐明。MiR-19b-3p参与了许多疾病的治疗,但它在EM相关不孕症中的功能作用仍未得到探讨。本研究旨在检测EM相关性不孕症患者精原细胞(CCs)和卵泡液中miR-19b-3p的丰度和IGF1的浓度,并通过确定miR-19b-3p的靶点和阐明其潜在机制,研究miR-19b-3p在KGN细胞中的潜在作用:病例对照研究结果表明,与输卵管性不孕患者组成的对照组相比,EM相关性不孕患者的成熟卵母细胞比例较低。在EM相关性不孕症患者的CC中,MiR-19b-3p水平升高。研究发现,IGF1是miR-19b-3p的直接靶标,并在KGN细胞中受miR-19b-3p的负调控。过表达 miR-19b-3p 能明显抑制 KGN 细胞的活力和增殖,促进细胞凋亡,并使细胞周期停滞在 G0/G1 期。同时转染 IGF1 后,miR-19b-3p 的作用被逆转,miR-19b-3p 对 KGN 细胞的生物效应是由 IGF1 介导的。此外,miR-19b-3p靶向IGF1下调AKT磷酸化,参与KGN细胞的凋亡通路:本研究表明,在EM相关性不孕症患者中,CCs中的miR-19b-3p水平升高,卵泡液中的IGF1浓度降低。MiR-19b-3p通过靶向IGF1调节KGN细胞的生物学效应。
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引用次数: 0
Research status of polycystic ovary syndrome treatment: a mini review and a bibliometric analysis from 2010 to 2023. 多囊卵巢综合征治疗的研究现状:2010 年至 2023 年的小型回顾和文献计量分析。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1080/09513590.2024.2405098
Yu-Xin Jin, Hang-Qi Hu, Jia-Cheng Zhang, Xi-Yan Xin, Yu-Tian Zhu, Hao-Lin Zhang, Rui-Wen Fan, Yang Ye, Dong Li

Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women, often linked to abdominal obesity, insulin resistance, and metabolic issues. With its heterogeneous nature, PCOS treatment should be tailored to individual symptoms and patient preferences. This study examines collaboration networks among countries, institutions, authors, references, and journals related to PCOS treatment.

Methods: Web of Science data was analyzed using VOSviewer and CiteSpace for bibliometric visualization. Chinese and Western medicine treatments for PCOS were reviewed, emphasizing symptom-targeted solutions.

Results: Data from 4682 records authored by 400 individuals from 515 institutes in 62 countries revealed China as the leading contributor. Notable authors include Monash University and Richard S. Legro. Common research themes include adipocytes, inflammation, insulin sensitivity, oxidative stress, and the gut microbiome. Tailoring treatment to individual needs is essential, focusing on hyperandrogenism, ovulation, and insulin resistance, with lifestyle counseling to address obesity.

Conclusion: This bibliometric analysis provides valuable insights into the research status of PCOS treatment. China has made significant contributions, and complementary and alternative therapies, such as traditional Chinese medicine and acupuncture, have also shown beneficial effects recently. The research on inflammation, oxidative stress, and the gut microbiome may provide new targets and strategies for the treatment of PCOS. The recognition of the metabolic problems in PCOS patients facilitates the formulation of more personalized treatment plans to improve the prognosis of patients.

背景:多囊卵巢综合征(PCOS)是绝经前妇女常见的内分泌和代谢疾病,通常与腹部肥胖、胰岛素抵抗和代谢问题有关。由于多囊卵巢综合症具有异质性,因此应根据个体症状和患者偏好进行治疗。本研究探讨了与多囊卵巢综合症治疗相关的国家、机构、作者、参考文献和期刊之间的合作网络:方法:使用 VOSviewer 和 CiteSpace 对 Web of Science 数据进行分析,以实现文献计量可视化。方法:使用 VOSviewer 和 CiteSpace 对 Web Science 数据进行文献计量学可视化分析,并对多囊卵巢综合征的中西医治疗方法进行回顾,强调针对症状的解决方案:来自 62 个国家 515 个机构的 400 位作者所撰写的 4682 条记录的数据显示,中国的贡献最大。著名作者包括莫纳什大学和 Richard S. Legro。共同的研究主题包括脂肪细胞、炎症、胰岛素敏感性、氧化应激和肠道微生物组。根据个人需求量身定制治疗方案至关重要,重点关注高雄激素、排卵和胰岛素抵抗,并通过生活方式咨询来解决肥胖问题:这项文献计量分析为了解多囊卵巢综合症治疗的研究现状提供了宝贵的见解。中国做出了重大贡献,传统中医和针灸等补充和替代疗法近来也显示出有益的效果。对炎症、氧化应激和肠道微生物组的研究可能会为多囊卵巢综合征的治疗提供新的靶点和策略。认识到多囊卵巢综合症患者的代谢问题有助于制定更加个性化的治疗方案,从而改善患者的预后。
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引用次数: 0
Statement of Retraction: The impact of letrozole on oocyte quality in assisted reproductive technology (ART); a randomized double-blind clinical trial. 撤回声明:来曲唑对辅助生殖技术(ART)中卵母细胞质量的影响;随机双盲临床试验。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1080/09513590.2024.2419765
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引用次数: 0
Enhanced glycolysis in the myometrium with ectopic endometrium of patients with adenomyosis: a preliminary study. 子宫腺肌症患者异位子宫内膜中糖酵解增强:一项初步研究。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-03-27 DOI: 10.1080/09513590.2024.2332411
Shiya Huang, Xueqian Huang, Xiaohui Wen, Xuehong Liu, Hongxia Ma, Linling Xie, Yishu Wang, Shanjia Liu, Yongge Guan, Kunyin Li

Objectives: The objective of this study was to investigate the glycolytic activity of adenomyosis, which is characterized by malignant biological behaviors including abnormal cell proliferation, migration, invasion, cell regulation, and epithelial-mesenchymal transition.

Methods: From January 2021 to August 2022, a total of 15 patients who underwent total hysterectomy for adenomyosis and 14 patients who had non-endometrial diseases, specifically with cervical squamous intraepithelial neoplasia and uterine myoma, were included in this study. Myometrium with ectopic endometrium from patients with adenomyosis while normal myometrium from patients in the control group were collected. All samples were confirmed by a histopathological examination. The samples were analyzed by liquid chromatography-mass spectrometry (LC-MS), real-time quantitative PCR, NAD+/NADH assay kit as well as the glucose and lactate assay kits.

Results: Endometrial stroma and glands could be observed within the myometrium of patients in the adenomyosis group. We found that the mRNA expressions of HK1, PFKFB3, glyceraldehyde-3-phospate dehydrogenase (GAPDH), PKM2, and PDHA as well as the protein expressions of PFKFB3 were elevated in ectopic endometrial tissues of the adenomyosis group as compared to normal myometrium of the control group. The level of fructose 1,6-diphosphate was increased while NAD + and NAD+/NADH ratio were decreased compared with the control group. Besides, increased glucose consumption and lactate production were observed in myometrium with ectopic endometrium.

Conclusions: We concluded that altered glycolytic phenotype of the myometrium with ectopic endometrium in women with adenomyosis may contribute the development of adenomyosis.

研究目的子宫腺肌症以细胞异常增殖、迁移、侵袭、细胞调控和上皮-间质转化等恶性生物学行为为特征,本研究旨在探讨子宫腺肌症的糖酵解活性:2021年1月至2022年8月,本研究共纳入15例因子宫腺肌症接受全子宫切除术的患者和14例患有非子宫内膜疾病的患者,特别是宫颈鳞状上皮内瘤变和子宫肌瘤患者。研究人员收集了子宫腺肌症患者异位内膜的子宫肌层和对照组患者正常的子宫肌层。所有样本均经组织病理学检查确认。样本采用液相色谱-质谱法(LC-MS)、实时定量 PCR、NAD+/NADH 检测试剂盒以及葡萄糖和乳酸检测试剂盒进行分析:结果:腺肌症组患者的子宫肌层中可观察到子宫内膜基质和腺体。我们发现,与对照组的正常子宫肌层相比,子宫腺肌症组异位内膜组织中 HK1、PFKFB3、甘油醛-3-磷酸脱氢酶(GAPDH)、PKM2 和 PDHA 的 mRNA 表达以及 PFKFB3 的蛋白表达均升高。与对照组相比,异位子宫内膜组织中 1,6-二磷酸果糖水平升高,而 NAD + 和 NAD+/NADH 比值下降。此外,还观察到异位子宫内膜的葡萄糖消耗和乳酸生成增加:我们认为,子宫腺肌症妇女异位内膜子宫肌层糖酵解表型的改变可能是子宫腺肌症发病的原因之一。
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引用次数: 0
Analyzing the infertility burden of polycystic ovarian syndrome in China: A comprehensive age-period-cohort analysis with future burden prediction (1990-2030). 中国多囊卵巢综合征不孕不育负担分析:综合年龄段队列分析及未来负担预测(1990-2030 年)。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-07-11 DOI: 10.1080/09513590.2024.2362251
DongYi Shen, Yang Wang, PanWei Hu, Cong Qi, Hong Yang

Objective: Polycystic ovarian syndrome (PCOS) is a common but complex endocrine disorder widely linked to infertility and miscarriage. This study assessed the correlation between PCOS and infertility.

Methods: Using the latest data from the Global Burden of Disease 2019 database, we conducted an in-depth assessment of the disease burden attributed to PCOS in China. This analysis was performed using the joinpoint regression, age-period-cohort, and autoregressive integrated moving average (ARIMA) models.

Results: Between 1990-2019, an upward trend was observed in the age-standardized prevalence of PCOS-related female infertility in China. Joinpoint regression analysis revealed an increasing trend in the age-standardized prevalence of PCOS-related female infertility burden indicators as well as the average annual percentage change and annual percentage change across all age groups in China. In terms of the cohort effect, the period rate ratios associated with the age-standardized prevalence of PCOS-related infertility increased steadily over time. The ARIMA model predicted a relatively swift upward trend in the age-standardized prevalence of PCOS-related infertility in China from 2020-2030.

Conclusion: The age-standardized prevalence of PCOS-related female infertility in China has increased between 1990-2019. The ARIMA model predicted that the age-standardized prevalence of this disease may continue to increase over the next decade. This study can increase the public's attention, improve women's health awareness, and have a certain significance for reducing female infertility related to PCOS.

目的:多囊卵巢综合征(PCOS多囊卵巢综合征(PCOS)是一种常见但复杂的内分泌疾病,与不孕和流产广泛相关。本研究评估了多囊卵巢综合征与不孕症之间的相关性:方法:利用《2019 年全球疾病负担》数据库中的最新数据,我们对中国多囊卵巢综合征导致的疾病负担进行了深入评估。结果:1990-2019年间,中国多囊卵巢综合征的发病率呈上升趋势:结果:1990-2019 年间,中国多囊卵巢综合征相关女性不孕症的年龄标准化患病率呈上升趋势。连接点回归分析显示,中国多囊卵巢综合征相关女性不孕负担指标的年龄标准化患病率以及各年龄组的年均百分比变化和年均百分比变化均呈上升趋势。在队列效应方面,与多囊卵巢综合症相关不孕症年龄标准化患病率相关的期间比率随着时间的推移稳步上升。根据 ARIMA 模型预测,2020-2030 年期间,中国多囊卵巢综合征相关不孕症的年龄标准化患病率将呈较快的上升趋势:结论:1990-2019年间,中国PCOS相关女性不孕症的年龄标准化患病率呈上升趋势。ARIMA模型预测,该疾病的年龄标准化患病率在未来十年内可能会继续上升。本研究可提高公众的关注度,提高女性的健康意识,对减少多囊卵巢综合征相关女性不孕症的发生具有一定的意义。
{"title":"Analyzing the infertility burden of polycystic ovarian syndrome in China: A comprehensive age-period-cohort analysis with future burden prediction (1990-2030).","authors":"DongYi Shen, Yang Wang, PanWei Hu, Cong Qi, Hong Yang","doi":"10.1080/09513590.2024.2362251","DOIUrl":"https://doi.org/10.1080/09513590.2024.2362251","url":null,"abstract":"<p><strong>Objective: </strong>Polycystic ovarian syndrome (PCOS) is a common but complex endocrine disorder widely linked to infertility and miscarriage. This study assessed the correlation between PCOS and infertility.</p><p><strong>Methods: </strong>Using the latest data from the Global Burden of Disease 2019 database, we conducted an in-depth assessment of the disease burden attributed to PCOS in China. This analysis was performed using the joinpoint regression, age-period-cohort, and autoregressive integrated moving average (ARIMA) models.</p><p><strong>Results: </strong>Between 1990-2019, an upward trend was observed in the age-standardized prevalence of PCOS-related female infertility in China. Joinpoint regression analysis revealed an increasing trend in the age-standardized prevalence of PCOS-related female infertility burden indicators as well as the average annual percentage change and annual percentage change across all age groups in China. In terms of the cohort effect, the period rate ratios associated with the age-standardized prevalence of PCOS-related infertility increased steadily over time. The ARIMA model predicted a relatively swift upward trend in the age-standardized prevalence of PCOS-related infertility in China from 2020-2030.</p><p><strong>Conclusion: </strong>The age-standardized prevalence of PCOS-related female infertility in China has increased between 1990-2019. The ARIMA model predicted that the age-standardized prevalence of this disease may continue to increase over the next decade. This study can increase the public's attention, improve women's health awareness, and have a certain significance for reducing female infertility related to PCOS.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2362251"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical parameters that predict a premature LH rise in patients undergoing ovarian stimulation for IVF. 预测接受卵巢刺激试管婴儿患者 LH 过早升高的临床参数。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-06-30 DOI: 10.1080/09513590.2024.2365913
Maya Nasatzky, Yonathan Belicha, Ofer Fainaru

Background: Normal reproductive function requires adequate regulation of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion. During ovarian stimulation for in-vitro fertilization (IVF), some patients will demonstrate an early rise in LH despite being treated with a gonadotropin releasing-hormone (GnRH) antagonist, sometimes necessitating cycle cancellation. Previous studies have demonstrated a possible link between a premature LH rise with ovarian response to gonadotropins. We sought to determine what clinical parameters can predict this premature LH rise and their relative contribution. Methods: A retrospective study of 382 patients who underwent IVF treatment at Rambam Medical Center. The patients were stratified into age groups. A model predicting premature LH rise based on clinical and demographic parameters was developed using both multiple linear regression and a machine-learning-based algorithm. Results: LH rise was defined as the difference between pre-trigger and basal LH levels. The clinical parameters that significantly predicted an LH rise were patient age, BMI, LH levels at stimulation outset, LH levels on day of antagonist administration, and total number of stimulation days. Importantly, when analyzing the data of specific age groups, the model's prediction was strongest in young patients (age 25-30 years, R2 = 0.88, p < .001) and weakest in older patients (age > 41 years, R2 = 0.23, p = .003). Conclusions: Using both multiple linear regression and a machine-learning-based algorithm of patient data from IVF cycles, we were able to predict patients at risk for premature LH rise and/or LH surge. Utilizing this model may help prevent IVF cycle cancellation and better timing of ovulation triggering.

背景:正常的生殖功能需要卵泡刺激素(FSH)和黄体生成素(LH)分泌的充分调节。在体外受精(IVF)的卵巢刺激过程中,尽管使用了促性腺激素释放激素(GnRH)拮抗剂,但一些患者仍会出现 LH 过早升高的现象,有时不得不取消周期。以往的研究表明,LH过早升高与卵巢对促性腺激素的反应可能存在联系。我们试图确定哪些临床参数可预测 LH 过早升高及其相对作用。研究方法对兰巴姆医疗中心接受试管婴儿治疗的 382 名患者进行回顾性研究。患者被分为不同的年龄组。采用多元线性回归和基于机器学习的算法,根据临床和人口学参数建立了预测 LH 过早升高的模型。结果显示LH升高被定义为触发前与基础LH水平之间的差值。能显著预测 LH 升高的临床参数包括患者年龄、体重指数、刺激开始时的 LH 水平、使用拮抗剂当天的 LH 水平以及刺激天数总数。重要的是,在分析特定年龄组的数据时,该模型对年轻患者的预测能力最强(25-30 岁,R2 = 0.88,41 岁,R2 = 0.23,p = .003)。结论通过对试管婴儿周期的患者数据进行多元线性回归和基于机器学习的算法,我们能够预测有LH过早升高和/或LH激增风险的患者。利用该模型有助于防止试管婴儿周期取消,并更好地把握排卵触发时机。
{"title":"Clinical parameters that predict a premature LH rise in patients undergoing ovarian stimulation for IVF.","authors":"Maya Nasatzky, Yonathan Belicha, Ofer Fainaru","doi":"10.1080/09513590.2024.2365913","DOIUrl":"https://doi.org/10.1080/09513590.2024.2365913","url":null,"abstract":"<p><p><b>Background:</b> Normal reproductive function requires adequate regulation of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion. During ovarian stimulation for in-vitro fertilization (IVF), some patients will demonstrate an early rise in LH despite being treated with a gonadotropin releasing-hormone (GnRH) antagonist, sometimes necessitating cycle cancellation. Previous studies have demonstrated a possible link between a premature LH rise with ovarian response to gonadotropins. We sought to determine what clinical parameters can predict this premature LH rise and their relative contribution. <b>Methods:</b> A retrospective study of 382 patients who underwent IVF treatment at Rambam Medical Center. The patients were stratified into age groups. A model predicting premature LH rise based on clinical and demographic parameters was developed using both multiple linear regression and a machine-learning-based algorithm. <b>Results:</b> LH rise was defined as the difference between pre-trigger and basal LH levels. The clinical parameters that significantly predicted an LH rise were patient age, BMI, LH levels at stimulation outset, LH levels on day of antagonist administration, and total number of stimulation days. Importantly, when analyzing the data of specific age groups, the model's prediction was strongest in young patients (age 25-30 years, <i>R</i><sup>2</sup> = 0.88, <i>p</i> < .001) and weakest in older patients (age > 41 years, <i>R</i><sup>2</sup> = 0.23, <i>p</i> = .003). <b>Conclusions:</b> Using both multiple linear regression and a machine-learning-based algorithm of patient data from IVF cycles, we were able to predict patients at risk for premature LH rise and/or LH surge. Utilizing this model may help prevent IVF cycle cancellation and better timing of ovulation triggering.</p>","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2365913"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of ultrasound elastography in polycystic ovary syndrome: a systematic review and meta-analysis. 超声弹性成像在多囊卵巢综合征中的诊断价值:系统回顾和荟萃分析。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-05-11 DOI: 10.1080/09513590.2024.2352139
Zhongtan Ruan, Zhen Yu, Qianyu Qin, Ying Tang

Objective: The main purpose of this systematic review and meta-analysis was to investigate the diagnostic value of ultrasound elastography in the evaluation of polycystic ovary syndrome (PCOS).

Methods: A comprehensive and methodical investigation was carried out in the databases of PubMed, EMBASE, Cochrane, Scopus, Web of Science, and China National Knowledge Infrastructure, covering the entire duration of these databases until October 18, 2023. The primary purpose of this research was to evaluate and contrast ovarian tissue elasticity in people with and without PCOS. The elasticity of ovarian tissue was quantified using standardized mean difference (SMD).

Results: A total of eight studies were ultimately selected for systematic evaluation and meta-analysis. Five studies used shear wave elastography (SWE) as a diagnostic tool, and it was discovered that women with PCOS had higher levels of ovarian shear wave elasticity than their healthy counterparts. The SMD was determined to be 1.86 kilopascal (95% CI: 1.27 to 2.44). Three studies were conducted using strain elastography (SE) to compare the ovarian strain ratio of patients with PCOS to that of a healthy control group. The SMD for the PCOS group was 2.07 (95% CI: 1.79 to 2.34), which indicated that the ovarian strain ratio was significantly higher in that group.

Conclusion: This systematic review and meta-analysis found that women with PCOS had stiffer ovarian tissue than women without the disorder. Ultrasound elastography may provide clinicians with value beyond 2D ultrasound in the diagnosis of PCOS.

目的本系统综述和荟萃分析的主要目的是研究超声弹性成像在评估多囊卵巢综合征(PCOS)中的诊断价值:在PubMed、EMBASE、Cochrane、Scopus、Web of Science和中国国家知识基础设施等数据库中进行了全面、有条理的调查,涵盖了这些数据库至2023年10月18日的全部时间。这项研究的主要目的是评估和对比多囊卵巢综合征患者和非患者的卵巢组织弹性。卵巢组织的弹性采用标准化平均差(SMD)进行量化:结果:最终共有八项研究被选中进行系统评估和荟萃分析。其中五项研究使用剪切波弹性成像(SWE)作为诊断工具,结果发现患有多囊卵巢综合症的女性的卵巢剪切波弹性水平高于健康女性。经测定,SMD 为 1.86 千帕斯卡(95% CI:1.27 至 2.44)。有三项研究使用应变弹性成像(SE)来比较多囊卵巢综合症患者与健康对照组的卵巢应变比率。多囊卵巢综合征组的SMD为2.07(95% CI:1.79至2.34),这表明该组患者的卵巢应变比明显较高:本系统综述和荟萃分析发现,患有多囊卵巢综合症的女性的卵巢组织比没有这种疾病的女性更僵硬。超声弹性成像在诊断多囊卵巢综合症方面为临床医生提供了超越二维超声的价值。
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引用次数: 0
Comparison of resumption of ovulation after cessation of oral contraceptives and medroxyprogesterone acetate in women with polycystic ovary syndrome. 多囊卵巢综合征妇女停用口服避孕药和醋酸甲羟孕酮后恢复排卵的比较。
IF 2 4区 医学 Q2 Medicine Pub Date : 2024-12-01 Epub Date: 2024-02-02 DOI: 10.1080/09513590.2024.2309349
Soo Jin Han, Hoon Kim, Seung-Yup Ku, Chang Suk Suh

Objective: Both oral contraceptive pills (OCPs) and cyclic medroxyprogesterone acetate (MPA) are widely used to control menstrual abnormalities in women with polycystic ovary syndrome (PCOS). We aimed to evaluate the chance of ovulation resumption after cessation of OCPs and MPA in women with PCOS.

Methods: A retrospective study was conducted of women with PCOS who were treated with OCPs or cyclic MPA from September 2015 to March 2019. After cessation of medication, ovulation was assessed using basal body temperature and/or measurement of serum progesterone. The odds ratio for ovulation resumption was assessed with multivariable logistic regression. Additionally, doubly robust analysis was performed with inverse-probability-weighted analysis and regression adjustment based on the covariate balancing propensity score to adjust for the effect of covariates on the treatment assignment.

Results: Among 272 women with PCOS, 136 were prescribed OCPs and 136 were prescribed cyclic MPA. Ovulation resumed in 18.4% of women (n = 25) after cessation of MPA and in 24.3% of women (n = 33) after cessation of OCPs. The odds of ovulation resumption in MPA users were comparable with those in OCP users (adjusted odds ratio (aOR) 1.00, 95% confidence interval (CI) 0.89-1.12). After multiple imputation due to missing values, the results did not change substantially (aOR 0.99, 95% CI 0.89-1.10).

Conclusions: Among women with PCOS, MPA users have a similar chance of ovulation resumption as OCP users after cessation of medication. Cyclic MPA can be a good alternative to OCPs in women for whom OCPs are contraindicated or who decline to take OCPs.

目的:口服避孕药(OCP)和环状醋酸甲羟孕酮(MPA)被广泛用于控制多囊卵巢综合征(PCOS)女性的月经异常。我们的目的是评估多囊卵巢综合征妇女停用 OCP 和 MPA 后恢复排卵的几率:我们对 2015 年 9 月至 2019 年 3 月期间接受 OCPs 或周期性 MPA 治疗的 PCOS 女性患者进行了一项回顾性研究。停药后,使用基础体温和/或测量血清孕酮评估排卵情况。采用多变量逻辑回归评估恢复排卵的几率。此外,还使用反概率加权分析和基于协变量平衡倾向评分的回归调整进行了双重稳健分析,以调整协变量对治疗分配的影响:在272名患有多囊卵巢综合征的妇女中,136人接受了OCPs治疗,136人接受了周期性MPA治疗。停用 MPA 后,18.4% 的妇女(n = 25)恢复排卵,停用 OCP 后,24.3% 的妇女(n = 33)恢复排卵。MPA使用者恢复排卵的几率与OCP使用者相当(调整后的几率比(aOR)为1.00,95%置信区间(CI)为0.89-1.12)。在因缺失值而进行多重估算后,结果没有发生重大变化(aOR 0.99,95% CI 0.89-1.10):结论:在患有多囊卵巢综合征的女性中,MPA使用者在停药后恢复排卵的几率与OCP使用者相似。对于禁用 OCP 或拒绝服用 OCP 的妇女,周期性 MPA 可以作为 OCP 的良好替代品。
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引用次数: 0
Transfer of preclinical study data on the influence of cimicifuga racemosaon functional changes in the hippocampus during menopause. 关于更年期海马功能变化的含羞草影响的临床前研究数据转移。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI: 10.1080/09513590.2024.2360066
Petra Stute, Hans-Heinrich Henneicke-von Zepelin, Petra Nicken

Menopausal transition in women involves complex neurobiochemical changes linked to ovarian dysfunction, resulting in symptoms like vasomotor symptoms (VMS), sleep disturbances, anxiety, and cognitive impairments. Hormone replacement therapy is the first-line treatment. However, many women are reluctant to use HRT or have contraindications toward HRT and seek for alternatives. Non-hormonal therapies with extracts of Cimicifuga racemosa rhizomes like the isopropanolic extract (iCR, black cohosh) offer a promising alternative. A preclinical pilot study exploring iCR's effects on gene expression in the hippocampus and hypothalamus of ovarectomized (OVX) rats mimicking menopausal conditions identified important signaling pathways and CNS-based contributions to the multitargeted modes of action of iCR. Especially in the hippocampus, iCR compensated effects of OVX on gene expression profiles. These changes are reflected by the genes AVPR1A, GAL, CALCA, HCRT, PNOC, ESR1, ESR2 and TAC3 contributing to the formation of hot flushes or thermoregulation as well as to secondary effects such as blood pressure, metabolism, hormonal regulation, homeostasis, mood regulation, neuroendocrine modulation, regulation of sleep and arousal, and in learning, memory and cognition. To understand the mechanisms in the brain of estrogen-depressed animals (OVX) and subsequent iCR treatment we combined the results of the pilot study with those of up-to-date literature and tried to transfer the current knowledge to humans during menopausal transition and adaptation. Focus was laid on changes in the hippocampal function, that is disturbed by hormonal fluctuations, but can also be brought back into balance by iCR.

女性更年期的过渡涉及复杂的神经生化变化,与卵巢功能失调有关,导致血管运动症状(VMS)、睡眠障碍、焦虑和认知障碍等症状。激素替代疗法是一线治疗方法。然而,许多妇女不愿意使用激素替代疗法,或者对激素替代疗法有禁忌症,因此她们寻求替代疗法。使用异丙醇提取物(iCR,黑升麻)等含羞草根茎提取物的非激素疗法是一种很有前景的替代疗法。一项临床前试验研究探索了 iCR 对卵巢切除(OVX)大鼠海马和下丘脑基因表达的影响,该研究模拟了更年期状况,确定了 iCR 的重要信号通路和基于中枢神经系统的多靶点作用模式。特别是在海马中,iCR 补偿了 OVX 对基因表达谱的影响。AVPR1A 基因、GAL 基因、CALCA 基因、HCRT 基因、PNOC 基因、ESR1 基因、ESR2 基因和 TAC3 基因反映了这些变化,它们对潮热的形成或体温调节以及血压、新陈代谢、激素调节、稳态、情绪调节、神经内分泌调节、睡眠和唤醒调节以及学习、记忆和认知等次要效应做出了贡献。为了了解雌激素抑制动物(OVX)和随后的 iCR 治疗在大脑中的作用机制,我们将试点研究的结果与最新文献结合起来,并试图将现有知识应用于更年期过渡和适应过程中的人类。重点放在海马功能的变化上,这种变化会受到荷尔蒙波动的干扰,但也可以通过 iCR 恢复平衡。
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引用次数: 0
Time-efficient consultation hours in the department of gynecological endocrinology. 妇科内分泌科的高效问诊时间。
IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI: 10.1080/09513590.2024.2396628
Anne-Sophie Berger, Marina Sourouni, Norman Bitterlich, Kerstin Blickenstorfer, Kai J Bühling, Irene Lambrinoudaki, Xiangyan Ruan, Katrin Schaudig, Michael von Wolff, Petra Stute

Background: The aim was to conduct a benchmark pilot study to find the best practice for consultation hours in the field of gynecological endocrinology. Suitable benchmarking participants were found in China, Germany, Greece, and Switzerland. Specifically, the study aimed to find the most time-efficient and beneficial consultation type in gynecological endocrinology focused on menopause and whether a shorter face-to-face consultation correlates with lower patient satisfaction.

Methods: This was an observational study. To analyze the processes of all benchmarking participants three tools were used: a measurement of time needed for the different consultation types, a questionnaire for patients and one for physicians. The primary endpoint was the time measurement of first consultations. Secondary endpoints were the time measurements of follow-up consultations and phone consultations and patient satisfaction.

Results: The mean overall duration of a first consultation differed from 20.4 min to 39.7 min (p = 0.003), mainly based on differences of the mean time to acquire the patient history, 5.6 to 21.6 min (p < 0.001). The percentage of patients who felt they had enough time to discuss questions ranged from 70% to 100% (p < 0.001). The percentage of patients who felt fully understood by their physician ranged from 62.5% to 92% (p = 0.006). The duration of a first consultation did not correlate with patients feeling well consulted (r=-0.048, p = 0.557).

Conclusions: A concise patient history that concentrates on the most relevant points can reduce the total consultation time. Reducing consultation time can be made without compromising how well patients feel consulted.

背景:目的是开展一项基准试点研究,以找到妇科内分泌学领域会诊时间的最佳做法。在中国、德国、希腊和瑞士找到了合适的基准参与者。具体而言,该研究旨在找出妇科内分泌学中最省时、最有益的咨询类型,重点关注更年期,以及面对面咨询时间较短是否与患者满意度较低相关:这是一项观察性研究。方法:这是一项观察性研究,使用了三种工具对所有基准参与者的就诊流程进行分析:测量不同就诊类型所需的时间、患者问卷和医生问卷。主要终点是首次问诊的时间测量。次要终点是复诊和电话咨询的时间测量以及患者满意度:首次问诊的平均总时长从 20.4 分钟到 39.7 分钟不等(P = 0.003),主要是获取患者病史的平均时间从 5.6 分钟到 21.6 分钟不等(P = 0.006)。首次问诊的时间与患者是否感觉问诊良好无关(r=-0.048,p=0.557):结论:简明扼要的病史,集中于最相关的要点,可以缩短总问诊时间。在缩短问诊时间的同时,也不会影响患者的就诊感受。
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Gynecological Endocrinology
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