Association of anti-C1q antibodies, adiponectin and HLA II genotype in Colombian patients with systemic lupus erythematosus with lupus nephritis

Q3 Health Professions Revista Colombiana de Reumatologia Pub Date : 2024-01-01 DOI:10.1016/j.rcreu.2022.03.004

Sebastián Molina-Ríos , Gerardo Quintana-López , Gustavo Aroca , Eduardo Egea , Antonio Iglesias-Gamarra

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Abstract

Objective

To establish associations between the development of lupus nephritis (LN) and the expression of antibodies against C1q (anti-C1q) and serum adiponectin as these biomarkers have been previously postulated to be associated with the presence of LN.

Materials and methods

A case–control study nested in a cohort was chosen. Patients with SLE with renal involvement were included. Measurement of antibodies against C1q, levels of adiponectin, and HLA expression DRB1 and DQB1 were evaluated. We searched for possible associations between the measured biomarkers and allelic HLA types found.

Results

One hundred and six patients were recruited with LN with a mean age of 35 years. Mean adiponectin levels were 16.9 μg/mL, and 60% of patients presented anti-C1q positivity. HLA DRB1*0404 and DRB1*1101 are protective factors for LN (OR: .42, p = .0030 and OR: 0.49, p = .046 respectively). HLA DRB1*0701 (OR: 3.15, p = .0452) and DRB1*0802 (OR: 8.3, p = .020) are susceptibility factors for LN. There was a tendency for association between anti-C1q positivity and high levels of adiponectin with type IV LN (OR 2.3 [95% CI: 0.68–8.2] and (OR: 2.67 [95% CI: .76–9.9] respectively). There was a tendency for association between anti-C1q positivity and HLA expression DRB1*0701 (OR 2.7 [95% CI: .81–11.5]), as well as high levels of adiponectin and HLA expression DRB1*0404 (OR 3.03 [95% CI: .92–12.8]). No association was found between anti-C1q and adiponectin with the expression of HLA DRB1*1501. There was positive correlation between levels of anti-C1q and the activity index in renal biopsy.

Conclusions

In the Colombian population there is a tendency for association of anti-C1q with the expression of HLA DRB1*07; however, the expression of other HLA II genes known as risk factors for LN, was not associated with the expression of anti-C1q, adiponectin or any specific type of LN.

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哥伦比亚系统性红斑狼疮合并狼疮性肾炎患者体内抗 C1q 抗体、脂肪连接蛋白和 HLA II 基因型的关系

目的确定狼疮性肾炎（LN）的发生与 C1q 抗体（抗 C1q）和血清脂肪连接蛋白的表达之间的关系，因为这些生物标志物以前曾被推测与 LN 的存在有关。研究对象包括肾脏受累的系统性红斑狼疮患者。对 C1q 抗体、脂肪连接蛋白水平以及 HLA 表达 DRB1 和 DQB1 进行了评估。结果共招募了 16 名 LN 患者，平均年龄为 35 岁。平均脂联素水平为 16.9 μg/mL，60% 的患者呈抗 C1q 阳性。HLA DRB1*0404 和 DRB1*1101 是 LN 的保护因素（OR：0.42，p = .0030 和 OR：0.49，p = .046）。HLA DRB1*0701（OR：3.15，p = .0452）和 DRB1*0802（OR：8.3，p = .020）是 LN 的易感因素。抗 C1q 阳性和高水平的脂联素与 IV 型 LN 有关联趋势（OR 分别为 2.3 [95% CI: 0.68-8.2] 和 (OR: 2.67 [95% CI: .76-9.9])。抗 C1q 阳性与 HLA 表达 DRB1*0701 之间存在关联趋势（OR：2.7 [95% CI：.81-11.5]），高水平的脂肪连素与 HLA 表达 DRB1*0404 之间也存在关联趋势（OR：3.03 [95% CI：.92-12.8]）。抗 C1q 和脂肪连蛋白与 HLA DRB1*1501 的表达之间没有关联。结论在哥伦比亚人群中，抗 C1q 与 HLA DRB1*07 的表达存在相关性；然而，被称为 LN 危险因素的其他 HLA II 基因的表达与抗 C1q、脂肪连接蛋白或任何特定类型 LN 的表达无关。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

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0.00%

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期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.