Collaborative biofluid analysis based multi-channel integrated wearable detection system for the monitoring of wound infection

Abstract

The infection monitoring of chronic wounds can effectively improve the quality of wound care. However, the widely used single variable intermittent monitoring of wound provides little available information, which leads to inaccurate diagnosis and untimely warnings. In this study, a collaborative biofluid analysis based multi-channel integrated wearable detection system was constructed for the continuous detection of analytes such as pH, uric acid (UA), and C-reactive protein (CRP) in wound exudates with time division multiplexing. Based on the functionally modification with nanomaterials, integrated screen-printed electrodes (iSPE) with three working electrodes were designed for the collaboratively analyzing of wound exudates. Through the development of integrated circuits, the multi-channel wearable detection printed circuit board was constructed. With a self-designed interface, this iSPE was stably connected to the printed circuit board and realized the detection of three targets in the range of pH 3–8, UA concentrations 5–500 μmol/L, and CRP concentrations 1–1000 ng/mL at the same time. Combined with a smartphone, these results were collaborated analyzed and transferred for health management. Therefore, this integrated wearable multi-channel detection system can provide reliable and continuous evaluations for early warning of infection and further treatment of chronic wounds.