Sensory Gating Networks in Normal-Hearing Adults With Minimal Tinnitus.

IF 1.4 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY American Journal of Audiology Pub Date : 2024-01-19 DOI:10.1044/2023_AJA-23-00122
Lauren Ralston, Julia Campbell, Phillip Gilley, Mashhood Nielson, Kristopher Brown
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Abstract

Purpose: The goal of this study was to observe sensory gating-related networks underlying cortical auditory evoked potential (CAEP) peak components in individuals with and without minimal tinnitus, as measured using the Tinnitus Handicap Inventory (THI). This analysis was performed on previously published sensory gating responses in normal-hearing adults with and without minimal tinnitus.

Method: Independent component analysis was performed for each individual CAEP gating component (Pa, P50, N1, and P2). Significant components were retained for source localization analyses within the following groups: no tinnitus, tinnitus with a THI score ≤ 6, and tinnitus with a THI score > 6. Brain source localization was performed on the gating difference wave for each component using standardized low-resolution brain electromagnetic tomography.

Results: Gating-related networks were identified within each group. Different regional sources were observed between groups, with parietal sources underlying the Pa and P50 components as tinnitus severity increased. A larger prefrontal regional activation was also shown for the N1 gating component as tinnitus severity increased. These results expand upon the functional gating responses via CAEP waveforms in a previously published study.

Conclusions: The auditory gating response, as measured via CAEPs, has previously been shown to significantly correlate with an increase in tinnitus severity in adults with normal hearing. The corresponding changes in the gating response appear to be supported by different cortical regions in those without tinnitus, those with a THI score ≤ 6, and those with a THI score > 6. Next, functional differences between localized cortical regions should be tested.

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患有轻微耳鸣的正常听力成年人的感觉门控网络
目的:本研究的目的是观察使用耳鸣障碍量表(THI)测量的有轻微耳鸣和无轻微耳鸣患者皮层听觉诱发电位(CAEP)峰值成分的感觉门控相关网络。该分析是根据以前发表的有轻微耳鸣和无轻微耳鸣的正常听力成年人的感觉门控反应进行的:对每个 CAEP 选通成分(Pa、P50、N1 和 P2)进行独立成分分析。在以下组别中,保留重要成分进行声源定位分析:无耳鸣、THI 评分≤ 6 分的耳鸣和 THI 评分大于 6 分的耳鸣。使用标准化低分辨率脑电磁断层扫描对每个成分的门控差波进行脑源定位:结果:在每个组别中都发现了与门控相关的网络。各组间观察到不同的区域源,随着耳鸣严重程度的增加,Pa 和 P50 成分的顶叶源也随之增加。随着耳鸣严重程度的增加,N1门控成分也显示出更大的前额叶区域激活。这些结果扩展了之前发表的一项研究中通过 CAEP 波形得出的功能门控反应:结论:在听力正常的成年人中,通过 CAEPs 测定的听觉门控反应与耳鸣严重程度的增加显著相关。在无耳鸣者、THI评分≤6分者和THI评分大于6分者中,门控反应的相应变化似乎得到了不同皮质区域的支持。接下来,应测试局部皮质区域之间的功能差异。
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来源期刊
American Journal of Audiology
American Journal of Audiology AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-OTORHINOLARYNGOLOGY
CiteScore
3.00
自引率
16.70%
发文量
163
审稿时长
>12 weeks
期刊介绍: Mission: AJA publishes peer-reviewed research and other scholarly articles pertaining to clinical audiology methods and issues, and serves as an outlet for discussion of related professional and educational issues and ideas. The journal is an international outlet for research on clinical research pertaining to screening, diagnosis, management and outcomes of hearing and balance disorders as well as the etiologies and characteristics of these disorders. The clinical orientation of the journal allows for the publication of reports on audiology as implemented nationally and internationally, including novel clinical procedures, approaches, and cases. AJA seeks to advance evidence-based practice by disseminating the results of new studies as well as providing a forum for critical reviews and meta-analyses of previously published work. Scope: The broad field of clinical audiology, including audiologic/aural rehabilitation; balance and balance disorders; cultural and linguistic diversity; detection, diagnosis, prevention, habilitation, rehabilitation, and monitoring of hearing loss; hearing aids, cochlear implants, and hearing-assistive technology; hearing disorders; lifespan perspectives on auditory function; speech perception; and tinnitus.
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