Broadening horizons: ferroptosis as a new target for traumatic brain injury

IF 6.3 1区 医学 Q1 DERMATOLOGY Burns & Trauma Pub Date : 2024-01-21 DOI:10.1093/burnst/tkad051
Ziqing Wei, Haihan Yu, Huijuan Zhao, Mingze Wei, Han Xing, Jinyan Pei, Yang Yang, Kaidi Ren
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Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with ~50 million people experiencing TBI each year. Ferroptosis, a form of regulated cell death triggered by iron ion-catalyzed and reactive oxygen species-induced lipid peroxidation, has been identified as a potential contributor to traumatic central nervous system conditions, suggesting its involvement in the pathogenesis of TBI. Alterations in iron metabolism play a crucial role in secondary injury following TBI. This study aimed to explore the role of ferroptosis in TBI, focusing on iron metabolism disorders, lipid metabolism disorders and the regulatory axis of system Xc−/glutathione/glutathione peroxidase 4 in TBI. Additionally, we examined the involvement of ferroptosis in the chronic TBI stage. Based on these findings, we discuss potential therapeutic interventions targeting ferroptosis after TBI. In conclusion, this review provides novel insights into the pathology of TBI and proposes potential therapeutic targets.
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拓宽视野:作为脑外伤治疗新靶点的铁蛋白沉积症
创伤性脑损伤(TBI)是导致全球死亡和残疾的主要原因,每年约有 5000 万人受到创伤性脑损伤。铁变态反应是一种由铁离子催化和活性氧诱导的脂质过氧化反应引发的调节性细胞死亡,已被确认为创伤性中枢神经系统疾病的潜在诱因,这表明铁变态反应与创伤性脑损伤的发病机制有关。铁代谢的改变在创伤性脑损伤后的继发性损伤中起着至关重要的作用。本研究旨在探讨铁变态反应在创伤性脑损伤中的作用,重点是铁代谢紊乱、脂代谢紊乱和创伤性脑损伤中 Xc- 系统/谷胱甘肽/谷胱甘肽过氧化物酶 4 的调节轴。此外,我们还研究了慢性创伤性脑损伤阶段的铁变态反应。基于这些发现,我们讨论了针对创伤性脑损伤后铁蛋白沉积的潜在治疗干预措施。总之,本综述提供了对创伤性脑损伤病理的新见解,并提出了潜在的治疗目标。
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来源期刊
Burns & Trauma
Burns & Trauma 医学-皮肤病学
CiteScore
8.40
自引率
9.40%
发文量
186
审稿时长
6 weeks
期刊介绍: The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.
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