Exploring the mixture assessment or allocation factor (MAF): A brief overview of the current discourse

Thomas Backhaus
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Abstract

The European Chemicals Strategy for Sustainability requests to include a mixture assessment factor (MAF) into the safety assessment of chemicals, in order to account for the elevated risks of chemical mixtures. This text first reflects on the conceptual background of the MAF, and then provides an overview of current stakeholder positions and of the studies attempting to quantify an appropriate size of the MAF.

Stakeholders from industry, civil society organizations (NGOs), and regulatory authorities have already put forth statements regarding the perceived advantages and disadvantages of the MAF approach, sometimes without providing detailed arguments. A consensus seems to emerge that the so-called MAFfactor is not a suitable instrument, due to its indiscriminatory nature that penalizes even chemicals that contribute only marginally to the mixture risk. Members of the larger MAFceiling family, in particular the MAFexact, overcome this limitation and are therefore suggested as the way forward.

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探索混合评估或分配系数(MAF):当前讨论概述
欧洲化学品可持续发展战略》要求在化学品安全评估中纳入混合物评估因子 (MAF),以考虑化学品混合物的高风险。本文首先反映了 MAF 的概念背景,然后概述了当前利益相关者的立场,以及试图量化 MAF 适当大小的研究。似乎出现了一种共识,即所谓的 MAF 因子并不是一个合适的工具,因为它具有不加区分的性质,甚至会惩罚那些对混合物风险影响很小的化学品。更大的 MAFceiling 系列,特别是 MAFexact,克服了这一局限性,因此被认为是未来的发展方向。
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来源期刊
Current opinion in toxicology
Current opinion in toxicology Toxicology, Biochemistry
CiteScore
8.50
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0.00%
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审稿时长
64 days
期刊最新文献
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