D A Kurakina, M Yu Kirillin, A V Khilov, V V Perekatova
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引用次数: 0
Abstract
We developed a novel machine-learning-based algorithm based on a gradient boosting regressor for three-dimensional pixel-by-pixel mapping of blood oxygen saturation based on dual-wavelength optoacoustic data. Algorithm training was performed on in silico data produced from Monte-Carlo-generated absorbed light energy distributions in tissue-like vascularized media for probing wavelengths of 532 and 1064 nm and the empirical instrumental function of the optoacoustic imaging setup with further validation of the independent in silico data. In vivo optoacoustic data for rabbit-ear vasculature was employed as a testing dataset. The developed algorithm allowed in vivo blood oxygen saturation mapping and showed clear differences in blood oxygen saturation values in veins at 15 °C and 43 °C due to functional arteriovenous anastomoses. These results indicated that dual-wavelength optoacoustic imaging could serve as a cost-effective alternative to complicated multiwavelength quantitative optoacoustic imaging.
期刊介绍:
Laser Physics Letters encompasses all aspects of laser physics sciences including, inter alia, spectroscopy, quantum electronics, quantum optics, quantum electrodynamics, nonlinear optics, atom optics, quantum computation, quantum information processing and storage, fiber optics and their applications in chemistry, biology, engineering and medicine.
The full list of subject areas covered is as follows:
-physics of lasers-
fibre optics and fibre lasers-
quantum optics and quantum information science-
ultrafast optics and strong-field physics-
nonlinear optics-
physics of cold trapped atoms-
laser methods in chemistry, biology, medicine and ecology-
laser spectroscopy-
novel laser materials and lasers-
optics of nanomaterials-
interaction of laser radiation with matter-
laser interaction with solids-
photonics