Is Mitochondrial DNA Copy Number from Human Blood Associated with Iron Deposits in the Brain?

IF 5.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants & redox signaling Pub Date : 2024-06-01 Epub Date: 2024-02-23 DOI:10.1089/ars.2023.0529
Qu Tian, David A Zweibaum, Luke C Pilling, Francesco Casanova, Yong Qian, Janice L Atkins, David Melzer, Jun Ding, Luigi Ferrucci
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人体血液中线粒体 DNA 的拷贝数与大脑中的铁沉积物有关吗?
铁超载与线粒体功能障碍有关。一些与铁和线粒体相关的指标显示出性别差异。目前还不清楚血液中的线粒体DNA拷贝数(mtDNAcn)是否与大脑或肝脏中的铁沉积有关,也不清楚这种关系是否因性别而异。在这项基于人群的研究中,我们发现在社区居住的成年人中,血液中较低的 mtDNAcn 与基底节和海马中较高的脑铁以及较多的肝脏脂肪有关,而与脑容量或肝脏铁无关。有趣的是,mtDNAcn 与基底节脑铁之间的关联在男性中更为突出。我们的观察结果提出了一个假设,即连接线粒体功能障碍和铁超载的机制可能因大脑和肝脏而异,也可能因性别而异。
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来源期刊
Antioxidants & redox signaling
Antioxidants & redox signaling 生物-内分泌学与代谢
CiteScore
14.10
自引率
1.50%
发文量
170
审稿时长
3-6 weeks
期刊介绍: Antioxidants & Redox Signaling (ARS) is the leading peer-reviewed journal dedicated to understanding the vital impact of oxygen and oxidation-reduction (redox) processes on human health and disease. The Journal explores key issues in genetic, pharmaceutical, and nutritional redox-based therapeutics. Cutting-edge research focuses on structural biology, stem cells, regenerative medicine, epigenetics, imaging, clinical outcomes, and preventive and therapeutic nutrition, among other areas. ARS has expanded to create two unique foci within one journal: ARS Discoveries and ARS Therapeutics. ARS Discoveries (24 issues) publishes the highest-caliber breakthroughs in basic and applied research. ARS Therapeutics (12 issues) is the first publication of its kind that will help enhance the entire field of redox biology by showcasing the potential of redox sciences to change health outcomes. ARS coverage includes: -ROS/RNS as messengers -Gaseous signal transducers -Hypoxia and tissue oxygenation -microRNA -Prokaryotic systems -Lessons from plant biology
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