Strategies for Preventing Esophageal Stenosis After Endoscopic Submucosal Dissection and Progress in Stem Cell-Based Therapies.

IF 5.1 2区 医学 Q2 CELL & TISSUE ENGINEERING Tissue Engineering. Part B, Reviews Pub Date : 2024-10-01 Epub Date: 2024-02-14 DOI:10.1089/ten.TEB.2023.0316
Shujun Ye, Jingjing Hu, Daxu Zhang, Shuo Zhao, Xiaonan Shi, Weilong Li, Jingyi Wang, Weiping Guan, Li Yan
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Abstract

Endoscopic submucosal dissection (ESD) has been widely used in the early neoplasia of the esophagus. However, postoperative esophageal stenosis is a big problem, particularly when a large circumferential proportion of esophageal mucosa is resected. Currently, there are several methods available to prevent esophageal stenosis after ESD, including steroid administration, esophageal stent implantation, and endoscopic balloon dilation (EBD). However, the therapeutic effects of these are not yet satisfactory. Stem cell-based therapies has shown promising potential in reconstructing tissue structure and restoring tissue function. In this study, we discussed the current strategies for preventing esophageal stenosis after ESD and perspectives of stem cell-based therapies for the prevention of esophageal stenosis.

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预防 ESD 后食管狭窄的策略和干细胞疗法的进展。
内镜粘膜下剥离术(ESD)已被广泛应用于食管早期肿瘤的治疗。然而,术后食管狭窄是一个大问题,尤其是当切除的食管粘膜周缘比例较大时。目前,有几种方法可以预防 ESD 术后食管狭窄,包括类固醇用药、食管支架植入和内镜下球囊扩张(EBD)。然而,这些方法的治疗效果尚不令人满意。以干细胞为基础的疗法在重建组织结构和恢复组织功能方面具有广阔的前景。在此,我们讨论了目前预防ESD后食管狭窄的策略,以及干细胞疗法预防食管狭窄的前景。
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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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