Is fear of disease progression associated with antiretroviral therapy adherence in persons with HIV/AIDS?

IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Journal of Health Psychology Pub Date : 2024-08-01 Epub Date: 2024-01-22 DOI:10.1177/13591053231224177
Chan-Woo Yeom, Hyeju Ha, Bong-Jin Hahm, Sun Hee Lee, Nam Joong Kim, Eun-Jung Shim
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Abstract

We examined the mediating role of depression and anxiety on the relationship between fear of disease progression (FoP) and antiretroviral therapy (ART) adherence and the moderating role of social support in the FoP-depression/anxiety-ART adherence relationship in persons with HIV/AIDS (PWHA). 202 PWHA completed self-report measures. Simple mediation and moderated mediation analyses were performed. FoP was directly and negatively associated with ART adherence, and the mediating role of depression in this relationship was significant. Indirect effect of FoP mediated by anxiety on ART adherence was not significant. The moderating effect of social support was significant in the FoP-depression pathway, while the indirect effect of FoP on ART adherence mediated by depression was greatest at a higher level of social support and lower level of FoP. The results suggest the relevance of high FoP and depression-mediated FoP in ART adherence and social support may attenuate the negative impact of FoP.

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对疾病恶化的恐惧是否与艾滋病毒/艾滋病患者坚持抗逆转录病毒疗法有关?
我们研究了抑郁和焦虑对艾滋病病毒感染者/艾滋病患者(PWHA)疾病进展恐惧(FoP)和坚持抗逆转录病毒疗法(ART)之间关系的中介作用,以及社会支持在疾病进展恐惧-抑郁/焦虑-坚持抗逆转录病毒疗法关系中的调节作用。202 名艾滋病感染者完成了自我报告测量。研究人员进行了简单中介分析和调节中介分析。FoP与坚持抗逆转录病毒疗法直接负相关,抑郁在这种关系中的中介作用显著。焦虑对坚持抗逆转录病毒疗法的间接影响不显著。在 FoP-抑郁路径中,社会支持的调节作用显著,而在较高的社会支持水平和较低的 FoP 水平下,由抑郁介导的 FoP 对坚持抗逆转录病毒疗法的间接影响最大。结果表明,在坚持抗逆转录病毒疗法的过程中,高FoP和抑郁介导的FoP具有相关性,而社会支持可能会减轻FoP的负面影响。
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来源期刊
Journal of Health Psychology
Journal of Health Psychology PSYCHOLOGY, CLINICAL-
CiteScore
7.50
自引率
3.10%
发文量
81
期刊介绍: ournal of Health Psychology is an international peer-reviewed journal that aims to support and help shape research in health psychology from around the world. It provides a platform for traditional empirical analyses as well as more qualitative and/or critically oriented approaches. It also addresses the social contexts in which psychological and health processes are embedded. Studies published in this journal are required to obtain ethical approval from an Institutional Review Board. Such approval must include informed, signed consent by all research participants. Any manuscript not containing an explicit statement concerning ethical approval and informed consent will not be considered.
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