Efficacy and safety of percutaneous ultrasound-guided thermal ablation in the treatment of cervical metastatic lymph nodes from papillary thyroid carcinoma.

Clinical hemorheology and microcirculation Pub Date : 2024-01-01 DOI:10.3233/CH-231998

Shen Zhang, Yunyun Liu, Bangguo Zhou, Huixiong Xu

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Abstract

Objective: To evaluate the efficacy and safety of percutaneous ultrasound-guided thermal ablation in the treatment of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma (PTC).

Materials and methods: A total of 77 patients with 79 LNs ablated by microwave ablation (MWA) or radiofrequency ablation (RFA) between September 2018 and October 2022 were enrolled in this study. After treatment, patients were followed up with measurement of diameters of LNs and serum thyroglobulin (s-Tg) at 1, 3, 6, and 12 months and annually thereafter. The paired t-test was used to compare the changes of s-Tg level, diameters of LNs before and after ablation.

Results: There were no serious complications related to ablation while one case of incomplete ablation in MWA was found during follow-up. The mean longest and shortest diameter of the ablated LNs reduced from 11.6 ± 4.3 mm to 5.0 ± 4.1 mm (p < 0.001), and from 6.1 ± 1.9 mm to 3.0 ± 2.5 mm (p < 0.001) at the last follow-up visit. Besides, the final volume reduction rate (VRR) was 61.8 ± 56.4% (range, -67.0 -100%). The complete disappearance rate was 46.8%, but there were 4 (5.1%) LNs becoming bigger than before. The average s-Tg level was 9.2 ± 26.6 ng/mL, a data significantly decreased to 3.7 ± 7.0 ng/mL at the last follow-up, but no statistical difference was shown.

Conclusion: Thermal ablation is an effective and safe modality for the treatment of metastatic LNs from PTC.

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经皮超声引导热消融治疗甲状腺乳头状癌颈部转移淋巴结的有效性和安全性。

目的评估经皮超声引导热消融治疗甲状腺乳头状癌（PTC）颈部转移淋巴结（LNs）的有效性和安全性：本研究共纳入了2018年9月至2022年10月期间通过微波消融（MWA）或射频消融（RFA）消融79个LNs的77例患者。治疗后，患者在1、3、6和12个月时接受随访，测量LN的直径和血清甲状腺球蛋白（s-Tg），此后每年测量一次。采用配对t检验比较消融前后s-Tg水平和LN直径的变化：随访期间未发现与消融相关的严重并发症，但发现一例 MWA 消融不全。消融后 LN 的平均最长和最短直径从 11.6 ± 4.3 mm 减小到 5.0 ± 4.1 mm（p 结论：热消融是一种有效的肿瘤治疗方法：热消融是治疗 PTC 转移 LN 的一种有效而安全的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical hemorheology and microcirculation

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