Role of FEF25-75 in characterizing outpatients with asthma in clinical practice.

Allergologie select Pub Date : 2024-01-12 eCollection Date: 2024-01-01 DOI:10.5414/ALX02453E

Giorgio Ciprandi, Irene Schiavetti

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Abstract

Background: Asthma is characterized by variable airflow limitation. FEF_25-75 has been proposed as a reliable marker for bronchial obstruction, especially when FEV₁ and FEV₁/FVC are normal.

Objectives: To investigate the role of FEF_25-75 in patients with asthma seen in clinical settings.

Materials and methods: The cross-sectional study included 439 (181 females and 255 males; mean age 39 years) outpatients with asthma who consecutively visited an allergy clinic for a routine assessment. History, physical examination, asthma control, and spirometry were evaluated.

Results: FEF_25-75 was impaired (< 65% of predicted) in 136 (31%) outpatients. Considering only subjects with normal FEV₁ and FEV₁/FVC, FEF_25-75 was impaired in 71 (19.6%) subjects. In this subset, impaired FEF_25-75 was associated with low FEV₁ and FEV₁/FVC values (OR 0.91 and 0.85, respectively), and presence of asthma symptoms (OR 2.19).

Conclusion: FEF_25-75 deserves adequate and careful consideration in patients with asthma and normal FEV₁ and FEV₁/FVC, as the presence of impaired FEF_25-75 in this subset suggests a more specific approach.

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FEF25-75 在临床实践中描述门诊哮喘患者特征的作用。

背景：哮喘的特点是不同程度的气流受限。FEF25-75被认为是支气管阻塞的可靠标志物，尤其是当FEV1和FEV1/FVC正常时：调查 FEF25-75 在临床哮喘患者中的作用：横断面研究纳入了 439 名（女性 181 名，男性 255 名；平均年龄 39 岁）连续到过敏诊所接受常规评估的哮喘门诊患者。对病史、体格检查、哮喘控制情况和肺活量进行了评估：结果：136 名门诊患者（31%）的 FEF25-75 值受损（低于预测值的 65%）。仅考虑 FEV1 和 FEV1/FVC 正常的受试者，71 名（19.6%）受试者的 FEF25-75 受损。在这一群体中，FEF25-75受损与FEV1和FEV1/FVC值偏低（OR分别为0.91和0.85）以及出现哮喘症状（OR为2.19）有关：结论：对于 FEV1 和 FEV1/FVC 值正常的哮喘患者，FEF25-75 值值得充分、仔细地考虑，因为在这部分患者中存在 FEF25-75 值受损的情况，建议采用更具针对性的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Allergologie select

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