Introduction to the Theme "Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment".

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-10-10 DOI:10.1146/annurev-pharmtox-090123-010552
Urs A Meyer, Susan G Amara, Terrence F Blaschke, Paul A Insel
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Abstract

The reviews in Volume 64 of the Annual Review of Pharmacology and Toxicology cover diverse topics. A common theme in many of the reviews is the interindividual variability in the clinical response to drugs. Highlighted areas include emerging developments in pharmacogenomics that can predict the personal risk for drug inefficacy and/or adverse drug reactions. Other reviews focus on the use of circulating biomarkers to define drug metabolism phenotypes and the effect of circadian regulation on drug response. Another emerging technology, digital twins that model individual patients, is used to generate computational simulations of drug effects and identify optimal personalized treatments. Another variable that may affect clinical outcomes, the nocebo response (an adverse reaction to a placebo), complicates clinical trials. These reviews further document that pharmacological individuality is an essential component of the concepts of personalized medicine and precision medicine and will likely have an important impact on patient care.

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药理学个体性:个性化和精准药物治疗的新见解和新策略 "主题介绍:个性化和精确药物治疗的新见解和新策略"。
药理学与毒理学年度综述》第 64 卷中的综述涉及多个主题。许多综述的共同主题是药物临床反应的个体差异。重点领域包括药物基因组学的新兴发展,它可以预测药物无效和/或药物不良反应的个人风险。其他综述侧重于使用循环生物标志物来定义药物代谢表型以及昼夜节律对药物反应的影响。另一项新兴技术是以个体患者为模型的数字双胞胎,用于对药物效果进行计算模拟,并确定最佳的个性化治疗方法。另一个可能影响临床结果的变量--"无知觉反应"(对安慰剂的不良反应)--使临床试验变得更加复杂。这些综述进一步证明,药理学个体化是个性化医疗和精准医疗概念的重要组成部分,很可能会对患者护理产生重要影响。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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