PREPARATION AND CHARACTERIZATION OF FICUS LACOR METALLIC PARTICLES BASED NANOGEL FOR WOUND HEALING ACTIVITY

Abstract

Objective: Since there is no evidence of silver nanoparticle preparation using the Ficus lacor plant, our present study was designed to synthesise silver nanoparticles using a Ficus lacor leaves extract, which was expected to show an enhanced wound healing activity with greater advantages of green synthesis. Methods: In the present study, silver nanoparticles were prepared using Ficus lacor leaf extract and the prepared nanoparticles were characterised by Ultraviolet-Visible spectroscopy and Particle size analysis later a topical gel is prepared and its effectiveness was evaluated by using animal excision wound model. Results: The study results showed that the Ficus lacor-based silver nanoparticle topical gel on an animal excision wound model exhibited almost similar wound healing activity in comparison with standard marketed product. Conclusion: This study concluded that Ficus lacor-silver nanoparticle gel showed considerable improvement in the excision wound model and hence this can be a promising candidate in wound healing.