Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.5003
Kolan Pallavi, H. K.
Objective: Polycystic ovary syndrome (PCOS) is considered to be the most common endocrine disorder in women of reproductive age. The objective of this study was to calculate the prevalence of PCOS in Navodaya group of institutions based on Rotterdam criteria. Methods: A prospective study of 500 girls of Navodaya group of institutions (school, medical, dental, and nursing, pharmacy, physiotherapy and engineering students) aged 13 to 25 y who underwent clinical examination. Out of which, 68 girls with oligomenorrhea and/or hirsutism were invited for biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam criteria. Results: Out of 500 girl students, 68 girls satisfied Rotterdam’s criteria for PCOS. Under the Rotterdam criteria, the estimated prevalence of PCOS in adolescent and young adult students was 13.6%. Conclusion: Prevalence of PCOS in adolescent and young adult students of Navodaya Group of Institutions was 13.6%. This draws attention to the issue of early diagnosis in adolescent girls.
{"title":"STUDY OF PREVALENCE OF POLYCYSTIC OVARIAN SYNDROME AMONG ADOLESCENT AND YOUNG ADULT STUDENTS OF NAVODAYA GROUP OF INSTITUTIONS","authors":"Kolan Pallavi, H. K.","doi":"10.22159/ijcpr.2024v16i4.5003","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.5003","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is considered to be the most common endocrine disorder in women of reproductive age. The objective of this study was to calculate the prevalence of PCOS in Navodaya group of institutions based on Rotterdam criteria.\u0000Methods: A prospective study of 500 girls of Navodaya group of institutions (school, medical, dental, and nursing, pharmacy, physiotherapy and engineering students) aged 13 to 25 y who underwent clinical examination. Out of which, 68 girls with oligomenorrhea and/or hirsutism were invited for biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam criteria.\u0000Results: Out of 500 girl students, 68 girls satisfied Rotterdam’s criteria for PCOS. Under the Rotterdam criteria, the estimated prevalence of PCOS in adolescent and young adult students was 13.6%.\u0000Conclusion: Prevalence of PCOS in adolescent and young adult students of Navodaya Group of Institutions was 13.6%. This draws attention to the issue of early diagnosis in adolescent girls.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intussusception is defined as the invagination of one segment of the bowel into an immediately adjacent segment of the bowel. It is common in children, and idiopathic ileocolic intussusception is the most common form. It is rare in adults, and again, hamartomatous polyposis is a rare cause of intussusception in adults. But, this complication is most frequent for patients with Peutz-Jeghers syndrome (PJS). It represents 5% of all intussusceptions and accounts for only 1–5% of intestinal obstruction in adults. PJS is a clinical diagnosis based on any one of the following World Health Organization criteria: three or more histologically confirmed Peutz-Jeghers polyps; any number of PJ polyps with a family history of PJS; characteristic, prominent, mucocutaneous pigmentation with a family history of PJS; or any number of Peutz-Jeghers polyps and characteristic prominent, mucocutaneous pigmentation. Here we report a case of intussusceptions in a 21 y old male with underlying PJ polyp in the intestine and mucocutaneous pigmentation.
{"title":"PEUTZ-JEGHERS POLYP AS A LEAD POINT FOR ILEOCOLIC INTUSSUSCEPTION IN A YOUNG FEMALE: A CASE REPORT","authors":"Smruti Ranjan Hota, Pragnya Paramita Mishra, Debashis Nanda","doi":"10.22159/ijcpr.2024v16i4.4099","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.4099","url":null,"abstract":"Intussusception is defined as the invagination of one segment of the bowel into an immediately adjacent segment of the bowel. It is common in children, and idiopathic ileocolic intussusception is the most common form. It is rare in adults, and again, hamartomatous polyposis is a rare cause of intussusception in adults. But, this complication is most frequent for patients with Peutz-Jeghers syndrome (PJS). It represents 5% of all intussusceptions and accounts for only 1–5% of intestinal obstruction in adults. PJS is a clinical diagnosis based on any one of the following World Health Organization criteria: three or more histologically confirmed Peutz-Jeghers polyps; any number of PJ polyps with a family history of PJS; characteristic, prominent, mucocutaneous pigmentation with a family history of PJS; or any number of Peutz-Jeghers polyps and characteristic prominent, mucocutaneous pigmentation. Here we report a case of intussusceptions in a 21 y old male with underlying PJ polyp in the intestine and mucocutaneous pigmentation.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.5018
Aditya Kashyap, Shaloo Negi, Smriti Sharma
Ocular cysticercosis, though rare, can be extraocular or intraocular. Ocular manifestations usually occur as a part of a systemic infection and can lead to partial or complete visual impairment over a 3-5 y period. The parasite reaches the posterior segment of the eye via the high-flow choroidal circulation through the short ciliary arteries. A 35 y old female patient presented to us with history of blurring of vision in right eye over one week. Fundus examination revealed an oval translucent cyst of about 4 mm in diameter. The patient underwent USG B scan, which revealed well-circumscribed cystic lesion in posterior vitreous.
眼囊尾蚴病虽然罕见，但可发生在眼外或眼内。眼部表现通常是全身感染的一部分，可在3-5年内导致部分或全部视力受损。寄生虫通过高流量脉络膜循环经睫状体短动脉到达眼球后段。一名 35 岁的女性患者因右眼视力模糊一周前来就诊。眼底检查发现一个直径约 4 毫米的椭圆形半透明囊肿。患者接受了 USG B 扫描，发现玻璃体后部有圆形囊肿病变。
{"title":"OCULAR CYSTICERCOSIS: A CASE REPORT","authors":"Aditya Kashyap, Shaloo Negi, Smriti Sharma","doi":"10.22159/ijcpr.2024v16i4.5018","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.5018","url":null,"abstract":"Ocular cysticercosis, though rare, can be extraocular or intraocular. Ocular manifestations usually occur as a part of a systemic infection and can lead to partial or complete visual impairment over a 3-5 y period. The parasite reaches the posterior segment of the eye via the high-flow choroidal circulation through the short ciliary arteries. A 35 y old female patient presented to us with history of blurring of vision in right eye over one week. Fundus examination revealed an oval translucent cyst of about 4 mm in diameter. The patient underwent USG B scan, which revealed well-circumscribed cystic lesion in posterior vitreous.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.4095
Farha Deeba Rajasab, Sherley S. Cherian, Rakesh Kalappa, Haripriya Ramachandran
Objective: Effective postoperative pain management is crucial for recovery and patient satisfaction. This study compares the efficacy and safety of transdermal buprenorphine, an opioid analgesic, with diclofenac, a non-steroidal anti-inflammatory drug (NSAID), for postoperative pain relief in elective below umbilical surgeries. Methods: Hundred patients undergoing elective below-umbilical surgeries were randomized into two groups to receive either a transdermal buprenorphine patch or a diclofenac patch. Pain scores using the Numeric Rating Scale (NRS), functional recovery assessed by the WOMAC Index, and patient satisfaction were measured at baseline, 1 w, 2 w, and 4 w post-application. Results: Both groups showed significant pain reduction over time. However, at 1 and 2 W post-application, the diclofenac group exhibited greater pain relief (p<0.001) and higher patient satisfaction. By the 4 w, differences in pain scores and WOMAC Index between the groups were not statistically significant, indicating similar long-term efficacy. Conclusion: While both transdermal buprenorphine and diclofenac patches are effective for postoperative pain management, diclofenac patches offer superior short-term relief and patient satisfaction. Tailoring pain management strategies to individual patient needs and recovery phases is essential for optimizing postoperative care.
目的：有效的术后疼痛管理对患者的康复和满意度至关重要。本研究比较了经皮丁丙诺啡（一种阿片类镇痛药）和双氯芬酸（一种非甾体抗炎药）在择期脐下手术中缓解术后疼痛的有效性和安全性。方法：100 名接受择期脐下手术的患者被随机分为两组，分别接受经皮丁丙诺啡贴片或双氯芬酸贴片。分别在基线、贴敷后1周、2周和4周测量使用数字评分量表（NRS）的疼痛评分、使用WOMAC指数评估的功能恢复情况以及患者满意度：结果：随着时间的推移，两组患者的疼痛均有明显减轻。结果：随着时间的推移，两组患者的疼痛均有明显减轻，但在用药后 1 W 和 2 W，双氯芬酸组的疼痛缓解程度更大（p<0.001），患者满意度更高。使用 4 W 后，两组的疼痛评分和 WOMAC 指数差异无统计学意义，这表明两组的长期疗效相似：结论：虽然透皮丁丙诺啡和双氯芬酸贴片都能有效控制术后疼痛，但双氯芬酸贴片的短期缓解效果和患者满意度更好。根据患者的不同需求和恢复阶段调整疼痛治疗策略对于优化术后护理至关重要。
{"title":"A COMPARATIVE STUDY OF TRANSDERMAL BUPRENORPHINE PATCH VERSUS TRANSDERMAL DICLOFENAC PATCH FOR POST-OPERATIVE ANALGESIA IN ELECTIVE BELOW UMBILICAL SURGERIES","authors":"Farha Deeba Rajasab, Sherley S. Cherian, Rakesh Kalappa, Haripriya Ramachandran","doi":"10.22159/ijcpr.2024v16i4.4095","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.4095","url":null,"abstract":"Objective: Effective postoperative pain management is crucial for recovery and patient satisfaction. This study compares the efficacy and safety of transdermal buprenorphine, an opioid analgesic, with diclofenac, a non-steroidal anti-inflammatory drug (NSAID), for postoperative pain relief in elective below umbilical surgeries.\u0000Methods: Hundred patients undergoing elective below-umbilical surgeries were randomized into two groups to receive either a transdermal buprenorphine patch or a diclofenac patch. Pain scores using the Numeric Rating Scale (NRS), functional recovery assessed by the WOMAC Index, and patient satisfaction were measured at baseline, 1 w, 2 w, and 4 w post-application.\u0000Results: Both groups showed significant pain reduction over time. However, at 1 and 2 W post-application, the diclofenac group exhibited greater pain relief (p<0.001) and higher patient satisfaction. By the 4 w, differences in pain scores and WOMAC Index between the groups were not statistically significant, indicating similar long-term efficacy.\u0000Conclusion: While both transdermal buprenorphine and diclofenac patches are effective for postoperative pain management, diclofenac patches offer superior short-term relief and patient satisfaction. Tailoring pain management strategies to individual patient needs and recovery phases is essential for optimizing postoperative care.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.5042
Nigel Jose, Aruna Bula, P. R. Kumari, P. Kamala
Methods: The present study was a prospective study conducted from April 2022 to March 2023 in 4551 patients. Samples of 238 patients newly diagnosed with HIV attending Integrated Counselling and Testing Centre (ICTC), Visakhapatnam, Andhra Pradesh, India and registered for Antiretroviral Therapy (ART) were taken. 5 ml of blood sample was collected aseptically and tested for HIV. The 238 HIV-positive samples were tested for CD4 counts at presentation and after 6 mo using flow cytometry (Sysmex Partec CyFlow Flow cytometer). They were further subjected to real-time RT-PCR to detect viral load at 6 mo follow-up. Results: Out of 238 HIV-positive cases, predominant gender being males with 140 (58.82%) and the predominant age group was 31-40 y. At 6 mo follow-up, 19 patients (8%) were diagnosed as having TB. The mean CD4 counts at baseline and after 6 mo of antiretroviral therapy (ART)) was 296±229 and 436±271 cells/mm3 (p value of<0.001) for entire study group. The mean baseline CD4 count in patients who were not diagnosed with TB at the time of follow-up and those who were diagnosed as having developed TB was 307±232 cells/mm3 and 167±135 cells/mm3 respectively. At six mo follow-up, 32(14.6%) HIV patients who did not develop TB and 8(42.1%) patients who developed TB still had their CD4 counts<200 cells/mm3. This was statistically significant with a p value=0.019. Significant difference was not found between the two subgroups as the HIV-only group had 192(87.7%) patients and 16(84.2%) patients from newly diagnosed TB patients had their viral loads below detection levels. Conclusion: low CD4 counts at the baseline was a high-risk factor for the development of tuberculosis in HIV patients. The viral load values at 6-month follow-up did not prove to be significantly linked to the development of tuberculosis.
{"title":"TUBERCULOSIS AND ITS ASSOCIATION WITH CD4+T CELL COUNT AND VIRAL LOAD AMONG HIV POSITIVE PATIENTS IN A TERTIARY CARE HOSPITAL","authors":"Nigel Jose, Aruna Bula, P. R. Kumari, P. Kamala","doi":"10.22159/ijcpr.2024v16i4.5042","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.5042","url":null,"abstract":"Methods: The present study was a prospective study conducted from April 2022 to March 2023 in 4551 patients. Samples of 238 patients newly diagnosed with HIV attending Integrated Counselling and Testing Centre (ICTC), Visakhapatnam, Andhra Pradesh, India and registered for Antiretroviral Therapy (ART) were taken. 5 ml of blood sample was collected aseptically and tested for HIV. The 238 HIV-positive samples were tested for CD4 counts at presentation and after 6 mo using flow cytometry (Sysmex Partec CyFlow Flow cytometer). They were further subjected to real-time RT-PCR to detect viral load at 6 mo follow-up.\u0000Results: Out of 238 HIV-positive cases, predominant gender being males with 140 (58.82%) and the predominant age group was 31-40 y. At 6 mo follow-up, 19 patients (8%) were diagnosed as having TB. The mean CD4 counts at baseline and after 6 mo of antiretroviral therapy (ART)) was 296±229 and 436±271 cells/mm3 (p value of<0.001) for entire study group. The mean baseline CD4 count in patients who were not diagnosed with TB at the time of follow-up and those who were diagnosed as having developed TB was 307±232 cells/mm3 and 167±135 cells/mm3 respectively. At six mo follow-up, 32(14.6%) HIV patients who did not develop TB and 8(42.1%) patients who developed TB still had their CD4 counts<200 cells/mm3. This was statistically significant with a p value=0.019. Significant difference was not found between the two subgroups as the HIV-only group had 192(87.7%) patients and 16(84.2%) patients from newly diagnosed TB patients had their viral loads below detection levels.\u0000Conclusion: low CD4 counts at the baseline was a high-risk factor for the development of tuberculosis in HIV patients. The viral load values at 6-month follow-up did not prove to be significantly linked to the development of tuberculosis.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.4086
K. I. D., U. S., E. K., Kavitha Manivannan, Malathi Ramasamy
The present study aims to enumerate the ethno-medicinal uses of plants by the Irular communities residing around the Thiruvallur district. The medicinal use of (49) plants belonging to 39 families was identified and recorded by the tribes, along with their botanical identities and methods of drug preparation. The drugs administered locally to heal wounds, including antibiotics, antiseptics, etc., and the necessary information related to the traditional medicinal plants were highlighted in this paper. Wound healing activity is a cellular and biochemical process for restoring the original structure and functions of damaged tissue. The wound may occur from a physical, chemical, thermal, microbial, or immunological insult to the tissues. Various parts of the plants have been in use for several years in tribal communities, traditionally for treating many diseases like skin, colic, sores, cancer, etc. Due to their minimal side effects. The natural agents present in the plants induce wound healing and regeneration from tissue loss by multiple mechanisms. Plant extracts have immense potential for the treatment of wound healing activity. In this review, we focused on the wound healing activity with the pharmacological process of medicinal plants.
{"title":"TRADITIONALLY USED MEDICINAL PLANTS FOR WOUND HEALING IN THIRUVALLUR DISTRICT, TAMIL NADU, INDIA","authors":"K. I. D., U. S., E. K., Kavitha Manivannan, Malathi Ramasamy","doi":"10.22159/ijcpr.2024v16i4.4086","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.4086","url":null,"abstract":"The present study aims to enumerate the ethno-medicinal uses of plants by the Irular communities residing around the Thiruvallur district. The medicinal use of (49) plants belonging to 39 families was identified and recorded by the tribes, along with their botanical identities and methods of drug preparation. The drugs administered locally to heal wounds, including antibiotics, antiseptics, etc., and the necessary information related to the traditional medicinal plants were highlighted in this paper. Wound healing activity is a cellular and biochemical process for restoring the original structure and functions of damaged tissue. The wound may occur from a physical, chemical, thermal, microbial, or immunological insult to the tissues. Various parts of the plants have been in use for several years in tribal communities, traditionally for treating many diseases like skin, colic, sores, cancer, etc. Due to their minimal side effects. The natural agents present in the plants induce wound healing and regeneration from tissue loss by multiple mechanisms. Plant extracts have immense potential for the treatment of wound healing activity. In this review, we focused on the wound healing activity with the pharmacological process of medicinal plants.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.5004
Shaloo Negi, Aditya Kashyap, Smriti Sharma
Objective: A good eye drops installation technique and its knowledge is vital for curing eye ailments and preventing eye from harmful effects of over-dose and under-dose of drugs. The current study assessed the eye drop installation technique and corrected it by imparting them education regarding the same. Methods: A total of 120 patients were enrolled in the cross-sectional study using consecutive sampling technique till the sample size was achieved in a tertiary care hospital. The participants were observed by the trained observers for their steps of technique for installing eye drops and the errors were noted which were corrected by the observers and followed up till 3 visits to observe a change in the steps of technique. Results: The mean age of study participants was 41.44±15.4 y. Majority of them were in the age group 18-30 y (35%), females (55.8%), and belonging to upper middle socio-economic status (31.7%). Majority of study participants had 6/6 VA in right eye (65%) and left eye (61.7%). “Drop land on first attempt” and “direct bottle towards eyes” showed maximum improvement of 45.8% each followed by “tilt head while putting” showed 45 % improvement between 1st visit and 3rd visit. “Trouble putting drops” showed least improvement by 20% between 1st and 3rd visit. All the favorable ophthalmic practices showed a statically significant (<0.05) increase in their proportion in each visit. Conclusion: A high prevalence of errors while installing eye drops among participants were observed which were improved by educating them about right steps, as observe in follow up visits.
{"title":"ASSESSMENT OF EYE DROP INSTALLATION TECHNIQUE AMONG PATIENTS ATTENDING OUTPATIENT CLINIC AT PT. JLNGMC, CHAMBA","authors":"Shaloo Negi, Aditya Kashyap, Smriti Sharma","doi":"10.22159/ijcpr.2024v16i4.5004","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.5004","url":null,"abstract":"Objective: A good eye drops installation technique and its knowledge is vital for curing eye ailments and preventing eye from harmful effects of over-dose and under-dose of drugs. The current study assessed the eye drop installation technique and corrected it by imparting them education regarding the same.\u0000Methods: A total of 120 patients were enrolled in the cross-sectional study using consecutive sampling technique till the sample size was achieved in a tertiary care hospital. The participants were observed by the trained observers for their steps of technique for installing eye drops and the errors were noted which were corrected by the observers and followed up till 3 visits to observe a change in the steps of technique.\u0000Results: The mean age of study participants was 41.44±15.4 y. Majority of them were in the age group 18-30 y (35%), females (55.8%), and belonging to upper middle socio-economic status (31.7%). Majority of study participants had 6/6 VA in right eye (65%) and left eye (61.7%). “Drop land on first attempt” and “direct bottle towards eyes” showed maximum improvement of 45.8% each followed by “tilt head while putting” showed 45 % improvement between 1st visit and 3rd visit. “Trouble putting drops” showed least improvement by 20% between 1st and 3rd visit. All the favorable ophthalmic practices showed a statically significant (<0.05) increase in their proportion in each visit.\u0000Conclusion: A high prevalence of errors while installing eye drops among participants were observed which were improved by educating them about right steps, as observe in follow up visits.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giant cell tumor of the tendon sheath (GCT-TS) is predominantly encountered in the hand, ranking as the second most common solid tumor after ganglion cysts. Contrary to its prevalence in the upper extremity, GCT-TS manifestation in the foot is exceptionally rare. This report delineates a unique presentation of GCT-TS in the foot of a 25 y old female, who presented with a painful, progressively enlarging mass in the lateral aspect of her foot. This case underscores the diagnostic challenges and therapeutic considerations in managing such an atypical presentation of GCT-TS.
{"title":"GIANT CELL TUMOUR OF TENDON SHEATH IN THE FOOT: A RARE CASE REPORT","authors":"Girish Garg, Raghuveer Meena, Sandeep Kumar, Mahaveer Meena","doi":"10.22159/ijcpr.2024v16i4.4093","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.4093","url":null,"abstract":"Giant cell tumor of the tendon sheath (GCT-TS) is predominantly encountered in the hand, ranking as the second most common solid tumor after ganglion cysts. Contrary to its prevalence in the upper extremity, GCT-TS manifestation in the foot is exceptionally rare. This report delineates a unique presentation of GCT-TS in the foot of a 25 y old female, who presented with a painful, progressively enlarging mass in the lateral aspect of her foot. This case underscores the diagnostic challenges and therapeutic considerations in managing such an atypical presentation of GCT-TS.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.22159/ijcpr.2024v16i4.4078
M. Haritha, BL Kudagi, Pathapati Mohan, V. Chandra, SK. Salma Kamal, R. Manchi, A. Nelavala
Objective: Plants have long been recognised for their wide range of biological properties, including antibacterial, analgesic, anticancer, antipyretic, and antihypertensive action. They are also a significant source of several chemicals with biological activity. The Rutaceae family consists of a small shrub Atlantia monophylla. It is available all over India. The leaves were employed as an insect repellent and to alleviate swellings. The root bark has been found to contain atalaphyllinine, atalantin, dehydroatalantin, cycloepiatalantin, and atalaphylline 3, 5-dimethyl ether. Essential oil extracted from the leaves was reported to have antimicrobial properties. Methods: To evaluate the phytochemicals Standard chemical methods for each o the compounds were used – like Tannins (0.1% ferric chloride), saponins (2 ml of water)/flavonoids (with NaOH), Alkaloids (Drangandooff reagent), protein (Million’s reagent) steroids (10% sulphuric acid), anthraquinones (aqueous ammonia), Phenols (lead acetate), terpenoids, (3% sulphuric acids) Carbohydrates (Benedict’s reagent). Disc plate method was used to evaluate the antimicrobial activity of the extract Results: The results of this study identified the presence of tannins, flavonoids, alkaloids, proteins, steroids, phenols, terpenoids, and carbohydrates in the AM extract. The microbiological studies revealed better inhibitions of microbes compared to standard drugs. Conclusion: Tannins, flavonoids, proteins, steroids, phenols, terpenoids, carbohydrates and alkaloids were extracted from the AM extract. The extract has significant microbiological action.
{"title":"PHYTOCHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY OF ATLANTIA MONOPHYLLA (AM) EXTRACT","authors":"M. Haritha, BL Kudagi, Pathapati Mohan, V. Chandra, SK. Salma Kamal, R. Manchi, A. Nelavala","doi":"10.22159/ijcpr.2024v16i4.4078","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.4078","url":null,"abstract":"Objective: Plants have long been recognised for their wide range of biological properties, including antibacterial, analgesic, anticancer, antipyretic, and antihypertensive action. They are also a significant source of several chemicals with biological activity. The Rutaceae family consists of a small shrub Atlantia monophylla. It is available all over India. The leaves were employed as an insect repellent and to alleviate swellings. The root bark has been found to contain atalaphyllinine, atalantin, dehydroatalantin, cycloepiatalantin, and atalaphylline 3, 5-dimethyl ether. Essential oil extracted from the leaves was reported to have antimicrobial properties.\u0000Methods: To evaluate the phytochemicals Standard chemical methods for each o the compounds were used – like Tannins (0.1% ferric chloride), saponins (2 ml of water)/flavonoids (with NaOH), Alkaloids (Drangandooff reagent), protein (Million’s reagent) steroids (10% sulphuric acid), anthraquinones (aqueous ammonia), Phenols (lead acetate), terpenoids, (3% sulphuric acids) Carbohydrates (Benedict’s reagent). Disc plate method was used to evaluate the antimicrobial activity of the extract\u0000Results: The results of this study identified the presence of tannins, flavonoids, alkaloids, proteins, steroids, phenols, terpenoids, and carbohydrates in the AM extract. The microbiological studies revealed better inhibitions of microbes compared to standard drugs.\u0000Conclusion: Tannins, flavonoids, proteins, steroids, phenols, terpenoids, carbohydrates and alkaloids were extracted from the AM extract. The extract has significant microbiological action.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141832827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Acne is a prevalent skin condition affecting a wide range of age groups, often leading to severe scarring if left untreated. The use of subcision combined with fractional CO2 laser therapy has been posited as a potentially more effective treatment method for atrophic acne scars compared to standalone laser treatment. Methods: This clinical trial was conducted at Asha Derma Clinic, Gorakhpur, Uttar Pradesh, from 30th March 2023 to 30th March 2024. Thirty patients with ice pick and rolling-type atrophic acne scars were enrolled. Participants were treated on one side of their face with five sessions of fractional CO2 laser and on the other side with one session of subcision with fractional CO2 laser combined with four sessions of fractional CO2 laser alone. Outcomes were assessed through scar improvement and patient satisfaction at 1, 2, and 6 mo post-treatment, with data analysis performed using ANOVA and the Wilcoxon rank-sum test. Results: Significant improvements were observed in both recovery levels and patient satisfaction. The combined method showed higher recovery percentages (40-65%, Mean±SD: 54.7±7) compared to the laser alone (30-55%, Mean±SD: 43±11.1), with a p-value of 0.0005. Patient satisfaction also favored the combined method (1.8-3, Mean±SD: 6.6±1.2) over laser treatment alone (1.6-4, Mean±SD: 5.2±1.8), with a p-value of 0.0007. Conclusion: The study demonstrated that subcision combined with fractional CO2 laser therapy significantly enhances recovery levels and patient satisfaction in the treatment of atrophic acne scars, suggesting a robust advantage of integrating both treatments.
{"title":"THE USE OF SUBCISION IN CONJUNCTION WITH FRACTIONAL CARBON DIOXIDE LASER TO IMPROVE ATROPHIC ACNE SCARS","authors":"Priyanka Sharma, Ajit Singh, Aditya Kumar Tripathi","doi":"10.22159/ijcpr.2024v16i4.5019","DOIUrl":"https://doi.org/10.22159/ijcpr.2024v16i4.5019","url":null,"abstract":"Objective: Acne is a prevalent skin condition affecting a wide range of age groups, often leading to severe scarring if left untreated. The use of subcision combined with fractional CO2 laser therapy has been posited as a potentially more effective treatment method for atrophic acne scars compared to standalone laser treatment.\u0000Methods: This clinical trial was conducted at Asha Derma Clinic, Gorakhpur, Uttar Pradesh, from 30th March 2023 to 30th March 2024. Thirty patients with ice pick and rolling-type atrophic acne scars were enrolled. Participants were treated on one side of their face with five sessions of fractional CO2 laser and on the other side with one session of subcision with fractional CO2 laser combined with four sessions of fractional CO2 laser alone. Outcomes were assessed through scar improvement and patient satisfaction at 1, 2, and 6 mo post-treatment, with data analysis performed using ANOVA and the Wilcoxon rank-sum test.\u0000Results: Significant improvements were observed in both recovery levels and patient satisfaction. The combined method showed higher recovery percentages (40-65%, Mean±SD: 54.7±7) compared to the laser alone (30-55%, Mean±SD: 43±11.1), with a p-value of 0.0005. Patient satisfaction also favored the combined method (1.8-3, Mean±SD: 6.6±1.2) over laser treatment alone (1.6-4, Mean±SD: 5.2±1.8), with a p-value of 0.0007.\u0000Conclusion: The study demonstrated that subcision combined with fractional CO2 laser therapy significantly enhances recovery levels and patient satisfaction in the treatment of atrophic acne scars, suggesting a robust advantage of integrating both treatments.","PeriodicalId":13875,"journal":{"name":"International Journal of Current Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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