The effects of short term citrulline malate supplementation on oxidative stress and muscle damage in trained soccer players

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2024-01-20 DOI:10.1016/j.hnm.2024.200242
Mohammad Sadegh Mirenayat , Mohammad Faramarzi , Mohammad Reza Ghazvini , Jahangir Karimian , Amir Hadi , Zahra Heidari , Mohammad Hossein Rouhani , Amirmansour Alavi Naeini
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Abstract

There is some evidence that citrulline malate (CM) limits the deleterious effect of oxidative stress in athletes, but its effect on team sports like soccer is not clear. Thus, the current research is designed to investigate the effect of short-term CM supplementation on oxidative stress and muscle damage markers in trained soccer players. In this randomized double-blind controlled trial, 28 healthy, highly-trained male soccer players were selected and randomly assigned into 2 groups to take 6 g/day CM or placebo for 7 days. Blood samples were then taken in a resting-state at baseline and 24 h after the 7-day supplement intervention; and serum malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), lactate dehydrogenase (LDH), creatine kinase (CK), and uric acid levels were measured. Compared to the baseline, CM significantly decreased serum uric acid levels (P = 0.03) and significantly increased serum LDH concentrations (P = 0.002). However, there were no significant changes in serum levels of MDA, CAT, GSH, TAC, SOD, LDH CK, and uric acid compared to the placebo group (P > 0.05). It appears that short-term CM supplementation does not improve oxidative stress and muscle damage in soccer players. Further investigations should be conducted to fully understand the effects of CM on soccer players.

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短期补充瓜氨酸苹果酸盐对足球运动员氧化应激和肌肉损伤的影响
有证据表明,瓜氨酸苹果酸盐(CM)可限制氧化应激对运动员的有害影响,但其对足球等团队运动的影响尚不明确。因此,目前的研究旨在调查短期补充 CM 对训练有素的足球运动员氧化应激和肌肉损伤指标的影响。在这项随机双盲对照试验中,研究人员选取了 28 名经过严格训练的健康男性足球运动员,并将他们随机分为两组,分别在 7 天内服用每天 6 克的中药或安慰剂。然后分别在基线休息状态和 7 天补充剂干预后的 24 小时内采集血液样本,并测量血清丙二醛 (MDA)、总抗氧化能力 (TAC)、过氧化氢酶 (CAT)、谷胱甘肽 (GSH)、超氧化物歧化酶 (SOD)、乳酸脱氢酶 (LDH)、肌酸激酶 (CK) 和尿酸水平。与基线相比,中药明显降低了血清尿酸水平(P = 0.03),明显提高了血清 LDH 浓度(P = 0.002)。然而,与安慰剂组相比,血清中的 MDA、CAT、GSH、TAC、SOD、LDH CK 和尿酸水平没有明显变化(P > 0.05)。由此看来,短期补充中药并不能改善足球运动员的氧化应激和肌肉损伤。要全面了解中药对足球运动员的影响,还需要进行进一步的研究。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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