The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-01-25 DOI:10.1007/s13659-024-00431-5

Geoffrey A. Cordell

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Abstract

Reacting to the challenges presented by the evolving nexus of environmental change, defossilization, and diversified natural product bioprospecting is vitally important for advancing global healthcare and placing patient benefit as the most important consideration. This overview emphasizes the importance of natural and synthetic medicines security and proposes areas for global research action to enhance the quality, safety, and effectiveness of sustainable natural medicines. Following a discussion of some contemporary factors influencing natural products, a rethinking of the paradigms in natural products research is presented in the interwoven contexts of the Fourth and Fifth Industrial Revolutions and based on the optimization of the valuable assets of Earth. Following COP28, bioprospecting is necessary to seek new classes of bioactive metabolites and enzymes for chemoenzymatic synthesis. Focus is placed on those performance and practice modifications which, in a sustainable manner, establish the patient, and the maintenance of their prophylactic and treatment needs, as the priority. Forty initiatives for natural products in healthcare are offered for the patient and the practitioner promoting global action to address issues of sustainability, environmental change, defossilization, quality control, product consistency, and neglected diseases to assure that quality natural medicinal agents will be accessible for future generations.

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药品安全与生物勘探的当代联系：优先考虑患者的未来视角。

应对环境变化、化石和多样化天然产品生物勘探之间不断发展的关系所带来的挑战，对于推动全球医疗保健事业的发展并将患者的利益作为最重要的考虑因素至关重要。本综述强调了天然药物和合成药物安全的重要性，并提出了全球研究行动的领域，以提高可持续天然药物的质量、安全性和有效性。在讨论了影响天然产品的一些当代因素之后，在第四次和第五次工业革命相互交织的背景下，以优化地球宝贵财富为基础，提出了对天然产品研究范式的重新思考。继 COP28 之后，有必要进行生物勘探，以寻找新的生物活性代谢物和化学合成酶。重点是那些以可持续的方式，将病人及其预防和治疗需求的维持作为优先事项的绩效和实践调整。本书为患者和从业人员提供了 40 项天然产品在医疗保健中的应用倡议，促进全球行动，解决可持续发展、环境变化、化石、质量控制、产品一致性和被忽视疾病等问题，以确保子孙后代能够获得优质的天然药物。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.