Age-related decline in social interaction is associated with decreased c-Fos induction in select brain regions independent of oxytocin receptor expression profiles

IF 1.7 Q3 CLINICAL NEUROLOGY Aging brain Pub Date : 2024-01-01 DOI:10.1016/j.nbas.2024.100107
J. Russell Ravenel , Amy E. Perkins , Angela Tomczik , Ana Defendini , Helen K. Strnad , Elena Varlinskaya , Terrence Deak , Robert L. Spencer
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Abstract

Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (c-Fos mRNA) of young (3 month) and old (18 month) female rats after brief 10 min exposure to a novel female rat in order to identify forebrain regions that show selective age-related alterations in their neural response to social investigation. We also measured relative oxytocin receptor expression (Oxtr mRNA) as a possible factor in age-related declines in c-Fos induction after social interaction. Young rats exposed to a social partner had a greater c-Fos mRNA response than those exposed to novel context alone in the lateral septum and septohypothalamic area, with blunted increases evident in old rats. In addition, c-Fos mRNA levels in the lateral septum were positively correlated with social investigative behavior. Interestingly, age-related differences in c-Fos gene induction were unrelated to the local amount of Oxtr expression within specific brain regions, although we found an age-related decline in Oxtr expression in the ventromedial hypothalamus. This functional neuroanatomical characterization may point to certain brain regions that are especially sensitive to age-related declines associated with social interaction behavior.

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与年龄相关的社交互动减少与特定脑区的 c-Fos 诱导减少有关,而与催产素受体表达谱无关
社会行为会随着年龄的增长而减少,我们以前曾发现老年雌鼠的社会调查行为大幅减少。在这项研究中,我们检测了年轻(3 个月)和年老(18 个月)的雌性大鼠在短暂接触一只新的雌性大鼠 10 分钟后的神经激活模式(c-Fos mRNA),以确定在对社会调查的神经反应中表现出与年龄相关的选择性改变的前脑区域。我们还测量了催产素受体的相对表达量(Oxtr mRNA),这可能是社交互动后与年龄相关的 c-Fos 诱导下降的一个因素。与单独暴露于新环境的大鼠相比,年轻大鼠暴露于社交伙伴时,其外侧隔膜和丘脑隔区的c-Fos mRNA反应更大,而老年大鼠的c-Fos mRNA反应明显减弱。此外,外侧隔的c-Fos mRNA水平与社会调查行为呈正相关。有趣的是,c-Fos基因诱导与年龄相关的差异与特定脑区中Oxtr的局部表达量无关,尽管我们发现腹内侧下丘脑中Oxtr的表达量下降与年龄相关。这种功能性神经解剖学特征可能表明,某些脑区对与社会交往行为相关的年龄相关性衰退特别敏感。
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Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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