Shashi B. Singh, Sambhawana Bhandari, Sadikshya Bhandari, Samikshya Bhandari, Rajshree Singh, William Y. Raynor, Soren Hess, Thomas J. Werner, Abass Alavi, Mona-Elisabeth Revheim
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引用次数: 0
Abstract
Rheumatoid Arthritis (RA) is a systemic inflammatory disorder that commonly presents with polyarthritis but can have multisystemic involvement and complications, leading to increased morbidity and mortality. The diagnosis of RA continues to be challenging due to its varied clinical presentations. In this review article, we aim to determine the potential of PET/CT to assist in the diagnosis of RA and its complications, evaluate the therapeutic response to treatment, and predict RA remission. PET/CT has increasingly been used in the last decade to diagnose, monitor treatment response, predict remissions, and diagnose subclinical complications in RA. PET imaging with [18F]-fluorodeoxyglucose ([18F]-FDG) is the most commonly applied radiotracer in RA, but other tracers are also being studied. PET/CT with [18F]-FDG, [18F]-NaF, and other tracers might lead to early identification of RA and timely evidence-based clinical management, decreasing morbidity and mortality. Although PET/CT has been evolving as a promising tool for evaluating and managing RA, more evidence is required before incorporating PET/CT in the standard clinical management of RA.
类风湿性关节炎(RA)是一种全身性炎症性疾病,通常表现为多关节炎,但也可有多系统受累和并发症,导致发病率和死亡率增加。由于其临床表现多种多样,RA 的诊断仍然具有挑战性。在这篇综述文章中,我们旨在确定 PET/CT 在协助诊断 RA 及其并发症、评估治疗反应和预测 RA 缓解方面的潜力。近十年来,PET/CT 越来越多地用于诊断、监测治疗反应、预测缓解和诊断 RA 亚临床并发症。使用[18F]-氟脱氧葡萄糖([18F]-FDG)的 PET 成像是最常用于 RA 的放射性示踪剂,但其他示踪剂也在研究之中。使用[18F]-FDG、[18F]-NaF和其他示踪剂的PET/CT可早期发现RA并及时进行循证临床治疗,从而降低发病率和死亡率。尽管 PET/CT 已逐渐成为评估和管理 RA 的一种有前途的工具,但在将 PET/CT 纳入 RA 的标准临床管理之前,还需要更多的证据。
期刊介绍:
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.