{"title":"Lesion-level quantitative Lu-177 PSMA SPECT/CT SUV metrics are associated with interim treatment response in mCRPC: a PET-correlated study.","authors":"Berkay Çağdaş, Elif Kardelen Çağdaş, Alptuğ Özer Yüksel, Hüseyin Şan, Nilüfer Yildirim","doi":"10.1007/s12149-026-02193-1","DOIUrl":"https://doi.org/10.1007/s12149-026-02193-1","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1007/s12149-026-02191-3
Phornpailin Pairodsantikul, Mizuki Matsushita, Mei Takahashi, Kyeong Min Kim, Hiroshi Watabe, Monchaya Nivorn, Paramest Wongsa, Miho Shidahara
{"title":"Development of energy deposition pixel kernel convolution for planar dosimetry in <sup>177</sup>Lu therapy.","authors":"Phornpailin Pairodsantikul, Mizuki Matsushita, Mei Takahashi, Kyeong Min Kim, Hiroshi Watabe, Monchaya Nivorn, Paramest Wongsa, Miho Shidahara","doi":"10.1007/s12149-026-02191-3","DOIUrl":"https://doi.org/10.1007/s12149-026-02191-3","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1007/s12149-026-02190-4
Peixuan Wu, Keji Hao, Yuan Li, Yue Wang, Yan Gao, Qian Wang
{"title":"The diagnostic and therapeutic value of FDG PET/CT for infectious diseases in FUO/IUO patients.","authors":"Peixuan Wu, Keji Hao, Yuan Li, Yue Wang, Yan Gao, Qian Wang","doi":"10.1007/s12149-026-02190-4","DOIUrl":"https://doi.org/10.1007/s12149-026-02190-4","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1007/s12149-026-02181-5
Amin Saber Tanha, Ramin Sadeghi, Hamidreza Ghorbani, Salman Soltani, Atena Aghaee, Leili Zarifmahmoudi, Keyvan Sadri, Hasan Mehrad-Majd, Mohammad Asl Zare
Objective: Sentinel lymph node (SLN) mapping in bladder cancer has the potential to improve nodal staging while minimizing the morbidity associated with pelvic lymph node dissection (PLND). However, its feasibility, diagnostic accuracy, and influencing factors-including tumor stage, neoadjuvant chemotherapy (NAC), and imaging modality-remain under investigation.
Materials and methods: In this prospective study, 35 patients with T1-T4 urothelial carcinoma undergoing radical cystectomy and bilateral PLND were enrolled. Preoperative cystoscopic peritumoral injection of 99mTc-phytate was followed by planar lymphoscintigraphy and SPECT/CT. Intraoperative SLN detection utilized a handheld gamma probe. SLN identification was compared with standard PLND findings using patient- and hemipelvis-based analyses to determine detection rates, sensitivity, and false-negative rates.
Results: A total of 54 SLNs were identified in 24 patients (37 hemipelves). Patient-based detection rates were 68.6% for intraoperative gamma probe, 51.4% for SPECT/CT, and 45.7% for planar imaging. Hemipelvis-based detection rates were 52.9%, 40.0%, and 34.3%, respectively. Detection rates were highest in T1-T2, NAC-positive patients, with 100% intraoperative localization. Histopathological analysis identified nodal metastases in seven patients; SLNs were identified in four patients, three of whom showed concordant SLN involvement, while one showed no SLN involvement. The patient-based false-negative rate was 25%, while hemipelvis-based analysis showed no false negatives. Aberrant SLNs outside the standard PLND template were identified in 6% of patients, highlighting variable lymphatic drainage.
Conclusion: SLN mapping in bladder cancer is technically feasible and identifies atypical drainage patterns, with performance influenced by tumor stage, NAC, and imaging modality. SLN mapping may complement PLND by improving anatomical staging and may ultimately allow more tailored or minimally invasive lymphadenectomy in selected patients.
{"title":"Lymphatic mapping and sentinel lymph node biopsy in urinary bladder cancer: A SPECT/CT-based experience.","authors":"Amin Saber Tanha, Ramin Sadeghi, Hamidreza Ghorbani, Salman Soltani, Atena Aghaee, Leili Zarifmahmoudi, Keyvan Sadri, Hasan Mehrad-Majd, Mohammad Asl Zare","doi":"10.1007/s12149-026-02181-5","DOIUrl":"https://doi.org/10.1007/s12149-026-02181-5","url":null,"abstract":"<p><strong>Objective: </strong>Sentinel lymph node (SLN) mapping in bladder cancer has the potential to improve nodal staging while minimizing the morbidity associated with pelvic lymph node dissection (PLND). However, its feasibility, diagnostic accuracy, and influencing factors-including tumor stage, neoadjuvant chemotherapy (NAC), and imaging modality-remain under investigation.</p><p><strong>Materials and methods: </strong>In this prospective study, 35 patients with T1-T4 urothelial carcinoma undergoing radical cystectomy and bilateral PLND were enrolled. Preoperative cystoscopic peritumoral injection of <sup>99m</sup>Tc-phytate was followed by planar lymphoscintigraphy and SPECT/CT. Intraoperative SLN detection utilized a handheld gamma probe. SLN identification was compared with standard PLND findings using patient- and hemipelvis-based analyses to determine detection rates, sensitivity, and false-negative rates.</p><p><strong>Results: </strong>A total of 54 SLNs were identified in 24 patients (37 hemipelves). Patient-based detection rates were 68.6% for intraoperative gamma probe, 51.4% for SPECT/CT, and 45.7% for planar imaging. Hemipelvis-based detection rates were 52.9%, 40.0%, and 34.3%, respectively. Detection rates were highest in T1-T2, NAC-positive patients, with 100% intraoperative localization. Histopathological analysis identified nodal metastases in seven patients; SLNs were identified in four patients, three of whom showed concordant SLN involvement, while one showed no SLN involvement. The patient-based false-negative rate was 25%, while hemipelvis-based analysis showed no false negatives. Aberrant SLNs outside the standard PLND template were identified in 6% of patients, highlighting variable lymphatic drainage.</p><p><strong>Conclusion: </strong>SLN mapping in bladder cancer is technically feasible and identifies atypical drainage patterns, with performance influenced by tumor stage, NAC, and imaging modality. SLN mapping may complement PLND by improving anatomical staging and may ultimately allow more tailored or minimally invasive lymphadenectomy in selected patients.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Subcutaneous/cutaneous uptake in the cancer-affected breast on <sup>18</sup>F-FDG PET/CT: association with post-surgical prognosis in breast cancer patients.","authors":"Yurika Kitano, Kanae K Miyake, Tomomi W Nobashi, Takayoshi Ishimori, Ryusuke Nakamoto, Sho Koyasu, Masako Kataoka, Yasuhide Takeuchi, Masakazu Toi, Yuji Nakamoto","doi":"10.1007/s12149-026-02188-y","DOIUrl":"https://doi.org/10.1007/s12149-026-02188-y","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1007/s12149-026-02189-x
Yurika Kitano, Kanae K Miyake, Tomomi W Nobashi, Takayoshi Ishimori, Ryusuke Nakamoto, Sho Koyasu, Masako Kataoka, Masakazu Toi, Yuji Nakamoto
{"title":"Correction: Locoregional indicators of systemic spread in breast cancer: insights from standard-of-care imaging and ¹⁸F-FDG PET/CT.","authors":"Yurika Kitano, Kanae K Miyake, Tomomi W Nobashi, Takayoshi Ishimori, Ryusuke Nakamoto, Sho Koyasu, Masako Kataoka, Masakazu Toi, Yuji Nakamoto","doi":"10.1007/s12149-026-02189-x","DOIUrl":"https://doi.org/10.1007/s12149-026-02189-x","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s12149-026-02187-z
Shuto Inaba, Yudai Nawano, Koichi Ogawa
{"title":"Accurate CT-free correction of attenuation, scatter, and aperture effects using deep learning in dedicated cardiac pinhole SPECT.","authors":"Shuto Inaba, Yudai Nawano, Koichi Ogawa","doi":"10.1007/s12149-026-02187-z","DOIUrl":"https://doi.org/10.1007/s12149-026-02187-z","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to the comment on \"Subcutaneous/cutaneous uptake in the cancer-affected breast on <sup>18</sup>F-FDG PET/CT: association with post-surgical prognosis in breast cancer patients\".","authors":"Yurika Kitano, Kanae K Miyake, Tomomi W Nobashi, Takayoshi Ishimori, Ryusuke Nakamoto, Sho Koyasu, Masako Kataoka, Yasuhide Takeuchi, Masakazu Toi, Yuji Nakamoto","doi":"10.1007/s12149-026-02186-0","DOIUrl":"https://doi.org/10.1007/s12149-026-02186-0","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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