Cytogenetic analysis of coke oven workers in Eastern Slovakia.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Central European journal of public health Pub Date : 2023-12-01 DOI:10.21101/cejph.a7845

Vincent Sedlák, Anton Bujňák, Andrej Gajdoš, Dagmar Gajdošová, Janka Poráčová, Mária Konečná, Jozef Fejér, Daniela Gruľová, Hedviga Vašková, Marta Mydlárová Blaščáková

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Abstract

Objective: Our study aimed to evaluate the extent of polycyclic aromatic hydrocarbon (PAH) exposure in coke oven workers from Eastern Slovakia by cytogenetic analysis of human peripheral lymphocytes.

Methods: A total of 81 peripheral blood samples were collected from PAH-exposed workers (mean age 45.84 ± 9.73 years) and 30 samples constituted the control group (41.93 ± 15.39 years). The samples were processed using routine cytological analysis. Conventional cytogenetic analysis of human peripheral lymphocytes has been used to evaluate the effects of PAHs.

Results: Comparison of the aberrant cells in the total exposed with the controls showed a significant difference (p < 0.05). A high level of significance (p < 0.001) was observed when comparing the gaps between the exposed group and the control group. There was a significant difference (p < 0.01) in aberrant cells and chromatid breaks (p < 0.05) in the GR1 working subgroup compared with the control group. The results of the correlation analysis did not show a significant relationship between the length of occupational exposure and the frequency of aberrant cells (r = 0.071, p = 0.529). Similarly, no association was observed between smoking among coke plant workers and the frequency of aberrant cells (r = 0.117, p = 0.538).

Conclusion: Cytogenetic analysis showed an increased frequency of chromosomal aberrations in coke oven workers in Eastern Slovakia.

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东斯洛伐克焦炉工人的细胞遗传学分析。

研究目的我们的研究旨在通过对人类外周淋巴细胞进行细胞遗传学分析，评估斯洛伐克东部焦炉工人接触多环芳烃（PAH）的程度：共收集了 81 份暴露于多环芳烃的工人（平均年龄为 45.84 ± 9.73 岁）的外周血样本和 30 份对照组样本（平均年龄为 41.93 ± 15.39 岁）。样本经常规细胞学分析处理。人类外周淋巴细胞的常规细胞遗传学分析被用来评估多环芳烃的影响：结果：总暴露量中的畸变细胞与对照组的畸变细胞比较显示出显著差异（P < 0.05）。在比较暴露组与对照组之间的差距时，观察到了高度的显著性（p < 0.001）。与对照组相比，GR1 工作亚组的畸变细胞和染色体断裂有明显差异（p < 0.01）（p < 0.05）。相关分析结果显示，职业接触时间长短与畸变细胞频率之间没有明显关系（r = 0.071，p = 0.529）。同样，在焦化厂工人吸烟与畸变细胞频率之间也未观察到任何关联（r = 0.117，p = 0.538）：细胞遗传学分析表明，斯洛伐克东部焦炉工人的染色体畸变频率增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central European journal of public health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： The Journal publishes original articles on disease prevention and health protection, environmental impacts on health, the role of nutrition in health promotion, results of population health studies and critiques of specific health issues including intervention measures such as vaccination and its effectiveness. The review articles are targeted at providing up-to-date information in the sphere of public health. The Journal is geographically targeted at the European region but will accept specialised articles from foreign sources that contribute to public health issues also applicable to the European cultural milieu.