Serum Gamma Glutamyl Transferase: Understanding its Contribution as a Potential Predictor of the Occurrence of Type 2 Diabetes.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Current diabetes reviews Pub Date : 2024-01-01 DOI:10.2174/0115733998260996231122054907
Sristi Anupam, Simran Goel, Karun Bhatti, Dinesh Kumar Mehta, Rina Das
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Abstract

Introduction: The liver and kidneys are the primary locations of the glutathione metabolism enzyme gamma-glutamyl transferase (GGT). The two main factors contributing to an increase are hepatic illnesses and excessive alcohol use. This study set out to test a theory on the predictive importance of the association between GGT and Type 2 diabetes mellitus. (T2DM).

Methods: In order to do this, we combed through PubMed, Google Scholar, Medline, and Science Direct for a wide range of information from previous studies. Attributes were established at the outset and compared to GGT concentration.

Result: GGT, present in most cells, absorbs glutathione for intracellular antioxidant defences. This study links GGT to hepatic enzymes including HDL, LDL, and triglyceride. LDL, triglycerides, AST, and ALT increased with GGT concentration, but LDL decreased. Because of obesity, GGT production rises with BMI. We found that greater GGT levels were associated with more T2DM after analysing data from multiple sources.

Conclusion: This literature review concludes that GGT is related to other factors such as BMI, HDL, AST, and triglycerides in the development of diabetes mellitus. Serum GGT was found to be a potential predictor of metabolic syndrome and T2DM.

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血清γ-谷氨酰转移酶:了解其作为 2 型糖尿病发病潜在预测因子的贡献。
简介肝脏和肾脏是谷胱甘肽代谢酶γ-谷氨酰转移酶(GGT)的主要存在部位。导致谷丙转氨酶升高的两个主要因素是肝脏疾病和过度饮酒。本研究旨在检验 GGT 与 2 型糖尿病(T2DM)之间关联的预测重要性理论。(方法:为此,我们查阅了 PubMed、Google Scholar、Medline 和 Science Direct,从以往的研究中获取了大量信息。一开始就确定了属性,并与 GGT 浓度进行了比较:GGT存在于大多数细胞中,可吸收谷胱甘肽,用于细胞内抗氧化防御。这项研究将 GGT 与肝脏酶(包括高密度脂蛋白、低密度脂蛋白和甘油三酯)联系起来。低密度脂蛋白、甘油三酯、谷草转氨酶和谷丙转氨酶会随着 GGT 浓度的升高而升高,但低密度脂蛋白会降低。由于肥胖,谷丙转氨酶会随着体重指数(BMI)的升高而升高。在对多种来源的数据进行分析后,我们发现 GGT 水平越高,T2DM 的发病率越高:本文献综述认为,在糖尿病的发病过程中,GGT 与其他因素(如体重指数、高密度脂蛋白、谷草转氨酶和甘油三酯)有关。研究发现,血清谷丙转氨酶是代谢综合征和 T2DM 的潜在预测因子。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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