Cross-species transmission and host range genes in poxviruses

IF 5.5 3区医学 Q1 Medicine Virologica Sinica Pub Date : 2024-04-01 DOI:10.1016/j.virs.2024.01.007

Chen-Hui Yang, A-Ling Song, Ye Qiu, Xing-Yi Ge

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Abstract

The persistent epidemic of human mpox, caused by mpox virus (MPXV), raises concerns about the future spread of MPXV and other poxviruses. MPXV is a typical zoonotic virus which can infect human and cause smallpox-like symptoms. MPXV belongs to the Poxviridae family, which has a relatively broad host range from arthropods to vertebrates. Cross-species transmission of poxviruses among different hosts has been frequently reported and resulted in numerous epidemics. Poxviruses have a complex linear double-strand DNA genome that encodes hundreds of proteins. Genes related to the host range of poxvirus are called host range genes (HRGs). This review briefly introduces the taxonomy, phylogeny and hosts of poxviruses, and then comprehensively summarizes the current knowledge about the cross-species transmission of poxviruses. In particular, the HRGs of poxvirus are described and their impacts on viral host range are discussed in depth. We hope that this review will provide a comprehensive perspective about the current progress of researches on cross-species transmission and HRG variation of poxviruses, serving as a valuable reference for academic studies and disease control in the future.

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痘病毒的跨物种传播和宿主范围基因。

由天花病毒（MPXV）引起的人类天花持续流行，引发了人们对 MPXV 和其他痘病毒未来传播的担忧。MPXV 是一种典型的人畜共患病毒，可感染人类并引起类似天花的症状。MPXV 属于痘病毒科，宿主范围相对较广，从节肢动物到脊椎动物都有可能感染。痘病毒在不同宿主之间跨物种传播的报道屡见不鲜，并曾引发流行病。痘病毒有一个复杂的线性双链 DNA 基因组，可编码数百种蛋白质。与痘病毒宿主范围相关的基因被称为宿主范围基因（HRGs）。本综述简要介绍了痘病毒的分类、系统发育和宿主，然后全面总结了目前有关痘病毒跨物种传播的知识。特别是描述了痘病毒的 HRGs，并深入讨论了它们对病毒宿主范围的影响。我们希望这篇综述能从一个全面的视角介绍当前痘病毒跨种传播和HRG变异的研究进展，为今后的学术研究和疾病控制提供有价值的参考。

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来源期刊

Virologica Sinica Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

7.70

自引率

1.80%

发文量

3149

期刊介绍： Virologica Sinica is an international journal which aims at presenting the cutting-edge research on viruses all over the world. The journal publishes peer-reviewed original research articles, reviews, and letters to the editor, to encompass the latest developments in all branches of virology, including research on animal, plant and microbe viruses. The journal welcomes articles on virus discovery and characterization, viral epidemiology, viral pathogenesis, virus-host interaction, vaccine development, antiviral agents and therapies, and virus related bio-techniques. Virologica Sinica, the official journal of Chinese Society for Microbiology, will serve as a platform for the communication and exchange of academic information and ideas in an international context. Electronic ISSN: 1995-820X; Print ISSN: 1674-0769