Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics.

IF 4.4 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Annals of Family Medicine Pub Date : 2024-11-01 DOI:10.1370/afm.22.s1.4766
Daniel Merenstein, Tina Tan, Keisha Herbin Smith
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Abstract

Context: Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. One of the most common indications for probiotic treatment is the prevention of antibiotic-associated diarrhea (AAD). Unfortunately, many probiotic products used for AAD are not supported by rigorous independent research, and often results in non-evidence-based usage. Additionally, it is not clear when is the most appropriate time to take a probiotic when on an antibiotic course. Objectives: The primary aim is to determine the ability of BB-12 to impact antibiotic-induced reduction in short chain fatty acid concentration (SCFA), as reflected by the levels of acetate on day 14. Secondarily to determine the ability of BB-12 to impact antibiotic-induced disruption of the gut microbiota with 16S rDNA profiling, with the addition of the time variable of probiotic consumption. Study Design and Interventions: A five group randomized controlled trial, finished in December 2022, we are currently analyzing all the data, but will be finished much prior to NAPCRG. All participants were given a 7-day prescription for amoxicillin-clavulanic acid 875mg taken twice daily. One group received no other interventions. While the other participants were broken into 4 groups. Two groups consumed the yogurt intervention (either yogurt+probiotic or control yogurt) four hours after the antibiotic and two groups consumed the yogurt intervention (either yogurt+probiotic or control yogurt) concomitantly with antibiotics. This timing question is important, as it is unknown if the optimal time for patients to administer probiotics is concurrently with, or after four hours following antibiotic consumption. Setting: Capital Areal Primary Care Practice Based Research Network. Population Studied: 118 participants, ages 18-65 years, generally healthy. Outcome Measures: Change in SCFA among the five groups, microbiome reduced disruption and clinically diagnosed diarrhea. Results: Study is complete and analysis is underway. Should have full results by end of July 2023, much before NAPCRG. .

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开展探索性试点研究,展示预防抗生素相关腹泻的机制和益生菌的作用。
背景:益生菌是活的微生物,适量使用可为宿主带来健康益处。益生菌治疗最常见的适应症之一是预防抗生素相关性腹泻(AAD)。遗憾的是,许多用于预防抗生素相关性腹泻的益生菌产品并没有得到严格的独立研究的支持,往往导致无证据的使用。此外,目前还不清楚在服用抗生素期间何时服用益生菌最合适。研究目的主要目的是确定 BB-12 是否能影响抗生素引起的短链脂肪酸浓度(SCFA)的降低,第 14 天的醋酸盐水平反映了这一点。其次,通过 16S rDNA 图谱确定 BB-12 对抗生素诱导的肠道微生物群破坏的影响能力,并增加服用益生菌的时间变量。研究设计与干预:这是一项五组随机对照试验,于 2022 年 12 月完成,我们目前正在分析所有数据,但将在 NAPCRG 之前完成。所有参与者都获得了为期 7 天的阿莫西林-克拉维酸 875 毫克处方,每天服用两次。其中一组没有接受其他干预措施。其他参与者被分成 4 组。两组在服用抗生素四小时后饮用酸奶干预剂(酸奶+益生菌或对照组酸奶),两组在服用抗生素的同时饮用酸奶干预剂(酸奶+益生菌或对照组酸奶)。这个时间问题非常重要,因为患者服用益生菌的最佳时间是与抗生素同时服用还是在服用抗生素四小时后服用尚不清楚。地点首都地区初级保健实践研究网络。研究人群: 118 名参与者,年龄在 18-65 岁之间,身体健康。结果测量:五组中 SCFA 的变化、微生物组减少的干扰和临床诊断的腹泻。研究结果研究已经完成,正在进行分析。到 2023 年 7 月底将得出完整结果,比 NAPCRG 早很多。.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Family Medicine
Annals of Family Medicine 医学-医学:内科
CiteScore
3.70
自引率
4.50%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Annals of Family Medicine is a peer-reviewed research journal to meet the needs of scientists, practitioners, policymakers, and the patients and communities they serve.
期刊最新文献
Prehospital Clinical Decision-Making for Medication Administration for Behavioral Emergencies. Rapid Antigen Testing in School Health Offices for Surveillance of SARS-CoV-2 and Influenza A. Assessment and comparison of the ILI case definition in clinical and school-based community settings: ORCHARDS/IISP. Efficacy and Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children on Antibiotics (PLAY ON). Exploratory Pilot Studies to Demonstrate Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics.
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