Marine natural products and human immunity: novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-01-29 DOI:10.1007/s13659-024-00432-4

Chunsong Hu

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Abstract

Marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake, sponge, soft coral, marine algae, and microalgae. As vital biomedical resources for the discovery of marine drugs, bioactive molecules, and agents, these MNPs have bioactive potentials of antioxidant, anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects, cancer treatment, and improvement of human immunity. This article reviews the role of MNPs on anti-infection of coronavirus, SARS-CoV-2 and its major variants (such as Delta and Omicron) as well as tuberculosis, H. Pylori, and HIV infection, and as promising biomedical resources for infection related cardiovascular disease (irCVD), diabetes, and cancer. The anti-inflammatory mechanisms of current MNPs against SARS-CoV-2 infection are also discussed. Since the use of other chemical agents for COVID-19 treatment are associated with some adverse effects in cardiovascular system, MNPs have more therapeutic advantages. Herein, it’s time to protect this ecosystem for better sustainable development in the new era of ocean economy. As huge, novel and promising biomedical resources for anti-infection of SARS-CoV-2 and irCVD, the novel potential mechanisms of MNPs may be through multiple targets and pathways regulating human immunity and inhibiting inflammation. In conclusion, MNPs are worthy of translational research for further clinical application.

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海洋天然产品与人类免疫力：抗 SARS-CoV-2 感染及相关心血管疾病的新型生物医学资源。

海洋天然产物（MNPs）和海洋生物包括海胆、海鞘或海鞘、海参、海蛇、海绵、软珊瑚、海藻和微藻。作为发现海洋药物、生物活性分子和制剂的重要生物医学资源，这些 MNPs 具有抗氧化、抗感染、抗炎、抗凝、抗糖尿病、治疗癌症和提高人体免疫力等生物活性潜力。本文综述了 MNPs 对冠状病毒、SARS-CoV-2 及其主要变种（如 Delta 和 Omicron）以及结核病、幽门螺杆菌和 HIV 感染的抗感染作用，以及作为有望治疗感染相关心血管疾病（irCVD）、糖尿病和癌症的生物医学资源。此外，还讨论了当前 MNPs 针对 SARS-CoV-2 感染的抗炎机制。由于使用其他化学制剂治疗 COVID-19 会对心血管系统产生一些不良影响，因此 MNPs 具有更多的治疗优势。因此，在新的海洋经济时代，是时候保护这一生态系统，以更好地实现可持续发展了。MNPs 作为抗 SARS-CoV-2 感染和虹膜心血管疾病的巨大、新颖和有前景的生物医学资源，其新的潜在机制可能是通过多靶点和途径调节人体免疫和抑制炎症。总之，MNPs 值得进行转化研究，以进一步应用于临床。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.