The Association Between Repeated Measured Febrile Episodes During Early Childhood and Attention Deficit Hyperactivity Disorder: A Large-Scale Population-Based Study.

IF 2.7 3区医学 Q2 PSYCHIATRY Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-01-28 DOI:10.1177/10870547231215289

Ariel Israel, Eugene Merzon, Beth Krone, Stephen V Faraone, Ilan Green, Avivit Golan Cohen, Shlomo Vinker, Shira Cohen, Shai Ashkenazi, Eli Magen, Abraham Weizman, Iris Manor

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Abstract

Objective: We examined the association between the number, magnitude, and frequency of febrile episodes during the 0 to 4 years of life and subsequent diagnosis of ADHD.

Methods: This population-based case-control study in an Israeli HMO, Leumit Health Services (LHS), uses a database for all LHS members aged 5 to 18 years between 1/1/2002 and 1/30/2022. The number and magnitude of measured fever episodes during the 0 to 4 years were recorded in individuals with ADHD (N = 18,558) and individually matched non-ADHD controls in a 1:2 ratio (N = 37,116).

Results: A significant, independent association was found between the number and magnitude of febrile episodes during the 0 to 4 years and the probability of a later diagnosis of ADHD. Children who never had a measured temperature >37.5°C had a significantly lower rate of ADHD (OR = 0.834, 95% CI [0.802, 0.866], p < .0001).

Conclusions: Febrile episodes during 0 to 4 years are associated with a significantly increased rate of a later diagnosis of ADHD in a doseresponse relationship.

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幼儿期反复测量的发热与注意力缺陷多动障碍之间的关系：大规模人群研究》。

目的我们研究了0至4岁期间发热发作的次数、程度和频率与随后诊断为多动症之间的关联：这项基于人群的病例对照研究在以色列的一家 HMO 机构 Leumit Health Services (LHS) 中进行，使用的数据库涵盖了 2002 年 1 月 1 日至 2022 年 1 月 30 日期间所有年龄在 5 至 18 岁之间的 LHS 会员。研究记录了多动症患者（18,558 人）和非多动症对照组（37,116 人）在 0 至 4 年间发烧的次数和程度：结果发现，0 至 4 岁期间发热的次数和程度与日后诊断为多动症的概率之间存在明显的独立关联。测量体温从未超过 37.5°C 的儿童患多动症的比例明显较低（OR = 0.834，95% CI [0.802，0.866]，p 结论：0 至 4 岁期间发热的次数和程度与日后诊断为多动症的概率之间存在明显的独立关联：0-4岁期间的发热与后来诊断为多动症的比例明显增加有剂量反应关系。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.