A Sensitive Probe of Meso-Cyanophenyl Substituted BODIPY Derivative as Fluorescent Chemosensor for the Detection of Multiple Heavy Metal Ions.

IF 2.6 4区化学 Q2 BIOCHEMICAL RESEARCH METHODS Journal of Fluorescence Pub Date : 2025-02-01 Epub Date: 2024-01-29 DOI:10.1007/s10895-024-03581-4

Xiaochuan Li, Xuyang Liu

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Abstract

A fluorescent turn-on chemosensor (BA) was constructed by attaching bis(pyridin-2-ylmethyl)-amine (DPA) unit to the BODIPY scaffold. It can give a prominent green/yellow fluorescent response selectivity with each of Zn²⁺/Hg²⁺/Cd²⁺/Ca²⁺/Mn²⁺/Pb²⁺/Al³⁺. The 1:1 stoichiometry of BA and metal ions was drawn from the analysis of Job's plot. The limit detection of BA in recognition of Zn²⁺/Hg²⁺/Cd²⁺/Ca²⁺/Mn²⁺/Pb²⁺/Al³⁺ is ranged in 50.8-146.6 nM. There exists a linear relationship between the fluorescence intensity and concentration of metal ions (Zn²⁺: 4-15 µM). The mechanism of fluorescence signal "turn-on" is based on the photo induced transfer (PET) in the excited state of BA. The coordinated metal ions significantly weakened the electron-donating ability nitrogen atom in DPA, thus recovering the emission character of BODIPY. The substituted group at the phenyl ring in meso-position of BODIPY scaffold determines the recognizable list of metal ions.

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中氰基苯基取代 BODIPY 衍生物作为荧光化学传感器检测多种重金属离子的灵敏探针。

通过在 BODIPY 支架上连接双（吡啶-2-基甲基）胺（DPA）单元，构建了一种荧光开启化学传感器（BA）。它能在 Zn2+/Hg2+/Cd2+/Ca2+/Mn2+/Pb2+/Al3+ 的作用下产生显著的绿/黄荧光反应选择性。根据约伯图分析得出了 BA 与金属离子的 1:1 配比。BA 识别 Zn2+/Hg2+/Cd2+/Ca2+/Mn2+/Pb2+/Al3+ 的检出限为 50.8-146.6 nM。荧光强度与金属离子浓度（Zn2+：4-15 µM）之间存在线性关系。荧光信号的 "开启 "机制是基于 BA 激发态的光诱导转移（PET）。配位金属离子大大削弱了 DPA 中氮原子的电子供能能力，从而恢复了 BODIPY 的发射特性。BODIPY 支架中间位置苯环上的取代基决定了金属离子的可识别列表。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorescence 化学-分析化学

CiteScore

4.60

自引率

7.40%

发文量

203

审稿时长

5.4 months

期刊介绍： Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.