Serum sRAGE levels in children with atopic dermatitis: a prospective study.

IF 1.4 4区医学 Q3 ALLERGY Postepy Dermatologii I Alergologii Pub Date : 2023-12-01 Epub Date: 2024-01-08 DOI:10.5114/ada.2023.133585

Hatice Eke-Gungor, Bilal Sagiroglu, Zehra Nur Can-Coskun, Derya Kocer, Çiğdem Karakukcu

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Abstract

Introduction: Atopic dermatitis (AD) is chronic inflammatory skin disorder. The receptor for advanced glycation end products (RAGE) plays a role in inflammatory reactions. The soluble form of RAGE (sRAGE) acts as a decoy to inhibit interactions of RAGE.

Aim: To determine serum sRAGE levels in children with AD.

Material and methods: AD diagnosis was made according to Hanifin and Rajka criteria. Disease severity was scored by the scoring atopic dermatitis (SCORAD) index. Skin prick testing (SPT), total immunoglobulin E (Ig E) and eosinophil counts were analysed. The sRAGE levels were determined using ELISA technique.

Results: The children, aged 0.4 to 2.0 years with AD (n = 65) were investigated in two groups according to the presence (AD+/Atopy+ [n = 40]) or absence (AD+/Atopy- [n = 25]) of SPT positivity. The comparisons were made with a healthy control group matched for age and sex. The medians (interquartile range) of sRAGE levels in patient and control groups were 8.43 (1.04-18.37) and 14.09 (6.35-28.64), respectively (p < 0.001). The medians (interquartile range) of sRAGE levels in AD+/Atopy+, AD+/Atopy- and control groups were 8.5 (3.1-17.27), 7.75 (1.04-18.37) and 14.09 (6.35-28.64), respectively (p = 0.004). Correlation analysis failed to reach significance with the disease severity sRAGE levels, total IgE levels and eosinophil counts.

Conclusions: To our knowledge, this is the first study investigating the association of sRAGE levels with AD and disease severity in childhood. Serum sRAGE levels are decreased in AD but not correlated with disease severity. sRAGE levels may be important in the AD disease process.

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特应性皮炎患儿的血清 sRAGE 水平：一项前瞻性研究。

简介：特应性皮炎（AD）是一种慢性炎症性皮肤病：特应性皮炎（AD）是一种慢性炎症性皮肤病。高级糖化终产物受体（RAGE）在炎症反应中发挥作用。RAGE的可溶性形式（sRAGE）是抑制RAGE相互作用的诱饵。目的：测定AD患儿的血清sRAGE水平：AD 诊断依据 Hanifin 和 Rajka 标准。根据特应性皮炎（SCORAD）评分指数对疾病严重程度进行评分。对皮肤点刺试验（SPT）、总免疫球蛋白 E（Ig E）和嗜酸性粒细胞计数进行了分析。使用 ELISA 技术测定了 sRAGE 水平：根据 SPT 阳性与否（AD+/Atopy+ [n = 40]），将 0.4 至 2.0 岁的 AD 患儿（n = 65）分为两组进行调查。与年龄和性别匹配的健康对照组进行比较。患者组和对照组的 sRAGE 水平中值（四分位数间距）分别为 8.43（1.04-18.37）和 14.09（6.35-28.64）（P < 0.001）。AD+/Atopy+ 组、AD+/Atopy- 组和对照组的 sRAGE 水平中位数（四分位间范围）分别为 8.5（3.1-17.27）、7.75（1.04-18.37）和 14.09（6.35-28.64）（p = 0.004）。与疾病严重程度 sRAGE 水平、总 IgE 水平和嗜酸性粒细胞计数的相关性分析未达到显著性：据我们所知，这是第一项研究儿童期sRAGE水平与AD和疾病严重程度的关系。AD患者的血清sRAGE水平会降低，但与疾病严重程度无关。

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