3D printed microfluidic valve on PCB for flow control applications using liquid metal

IF 3 4区 医学 Q3 ENGINEERING, BIOMEDICAL Biomedical Microdevices Pub Date : 2024-01-30 DOI:10.1007/s10544-024-00697-z
Ahmed Hamza, Anagha Navale, Qingchuan Song, Sagar Bhagwat, Frederik Kotz-Helmer, Pegah Pezeshkpour, Bastian E. Rapp
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Abstract

Direct 3D printing of active microfluidic elements on PCB substrates enables high-speed fabrication of stand-alone microdevices for a variety of health and energy applications. Microvalves are key components of microfluidic devices and liquid metal (LM) microvalves exhibit promising flow control in microsystems integrated with PCBs. In this paper, we demonstrate LM microvalves directly 3D printed on PCB using advanced digital light processing (DLP). Electrodes on PCB are coated by carbon ink to prevent alloying between gallium-based LM plug and copper electrodes. We used DLP 3D printers with in-house developed acrylic-based resins, Isobornyl Acrylate, and Diurethane Dimethacrylate (DUDMA) and functionalized PCB surface with acrylic-based resin for strong bonding. Valving seats are printed in a 3D caterpillar geometry with chamber diameter of 700 µm. We successfully printed channels and nozzles down to 90 µm. Aiming for microvalves for low-power applications, we applied square-wave voltage of 2 Vpp at a range of frequencies between 5 to 35 Hz. The results show precise control of the bistable valving mechanism based on electrochemical actuation of LMs.

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印刷电路板上的 3D 打印微流控阀门,用于使用液态金属的流量控制应用。
在印刷电路板基底上直接三维打印有源微流体元件,可高速制造用于各种健康和能源应用的独立微器件。微阀是微流控设备的关键元件,液态金属(LM)微阀在与印刷电路板集成的微系统中表现出良好的流量控制能力。在本文中,我们展示了利用先进的数字光处理技术(DLP)直接在印刷电路板上三维打印的液态金属微阀。印刷电路板上的电极涂有碳墨,以防止镓基 LM 插头与铜电极之间发生合金化。我们使用 DLP 3D 打印机和自主开发的丙烯酸树脂(丙烯酸异冰片酯和二甲基丙烯酸二聚氨酯酯 (DUDMA)),并用丙烯酸树脂对 PCB 表面进行功能化处理,以实现牢固的粘合。阀座以三维履带式几何形状打印,腔体直径为 700 微米。我们成功打印出了最小 90 微米的通道和喷嘴。针对低功耗应用的微型阀门,我们在 5 至 35 Hz 的频率范围内施加了 2 Vpp 的方波电压。结果表明,基于 LM 的电化学致动,可以精确控制双稳态阀机制。
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来源期刊
Biomedical Microdevices
Biomedical Microdevices 工程技术-工程:生物医学
CiteScore
6.90
自引率
3.60%
发文量
32
审稿时长
6 months
期刊介绍: Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.
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