Surgical therapy of chronic lung allograft dysfunction.

Q4 Medicine Rozhledy v Chirurgii Pub Date : 2023-01-01 DOI:10.33699/PIS.2023.102.9.345-351
R Novysedlák, J Tavandžis, J Balko, Z Ozaniak Střížová, J Vachtenheim, R Lischke
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Abstract

Lung transplantation has become a standardized and widely accepted treatment modality for selected end-stage lung diseases. Many factors influ- ence the long-term survival of patients after lung transplantation. One of the most important is clearly the development of chronic lung allograft dysfunction (CLAD). This review summarizes current knowledge of the histopathology of CLAD and its clinical characteristics. It also describes lung re-transplantation as the only causal therapy, its possible complications, and outcomes in standard and high-urgency patients awaiting a suitable organ with extracorporeal membrane oxygenation support. Fundoplication is an important surgical modality potentially leading to an improvement of the patients' condition. The indications and outcomes of this surgical procedure are discussed in a separate chapter. In addition, several nonsurgical treatment options aimed at slowing the progression of CLAD are outlined, as well as ongoing research focused on extending the life of these patients.

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慢性肺移植功能障碍的手术治疗。
肺移植已成为治疗特定终末期肺病的一种标准化且广为接受的治疗方式。影响肺移植术后患者长期生存的因素很多。其中最重要的显然是慢性肺移植功能障碍(CLAD)的发生。本综述总结了目前对 CLAD 组织病理学及其临床特征的了解。它还介绍了作为唯一因果疗法的肺再移植、其可能出现的并发症,以及在体外膜氧合支持下等待合适器官的标准病人和高危重病人的治疗效果。胃底折叠术是一种重要的手术方式,有可能改善患者的病情。该手术的适应症和结果将在另一章中讨论。此外,还概述了几种旨在延缓 CLAD 病程进展的非手术治疗方案,以及正在进行的旨在延长这些患者生命的研究。
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来源期刊
Rozhledy v Chirurgii
Rozhledy v Chirurgii Medicine-Medicine (all)
CiteScore
0.50
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0.00%
发文量
67
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