A New and Efficient Electro Organic Method for Synthesis of Methyl Cinnamate Derivatives via Heck Reaction Under Green Conditions

Abstract

In recently years, the field of organic chemistry has seen a growing interest in the development of environmentally friendly and efficient synthetic methods. In this context, we introduce a new electro-organic approach for the synthesis of methyl cinnamate derivatives through the Heck reaction, carried out under green conditions. The conventional Heck reaction, widely used for synthesizing diverse compounds, suffers from drawbacks like the use of toxic solvents, harsh reaction conditions, and the generation of waste. To address these challenges, we employed an electrochemical method, offering a more sustainable alternative. Our electro-organic process utilized a two-electrode setup with easily available anode and cathode materials. Through the application of an appropriate potential difference, both the aryl halide and olefin substrates were electrochemically activated, leading to the formation of the desired methyl cinnamate derivatives. This innovative approach offers several significant advantages. Firstly, it eliminates the need for toxic catalysts, reducing the environmental impact related to waste disposal. Secondly, the mild reaction conditions allow for the use of a broad range of functional groups, enabling the synthesis of diverse methyl cinnamate derivatives. Moreover, the electrochemical approach demonstrates exceptional selectivity and efficiency, resulting in high product yields. Additionally, the method is easily scalable, making it suitable for large-scale production. The affordability and accessibility of the electrode materials further contribute to the sustainability of the process. In summary, our electro-organic method represents a greener and more efficient strategy for synthesizing methyl cinnamate derivatives via the Heck reaction. It not only addresses the limitations of conventional methods but also aligns with the principles of sustainable chemistry. We expect this novel methodology to find widespread applications in the synthesis of various important compounds, promoting the development of more sustainable chemical processes.

Graphical Abstract