Sylvester I. Omoruyi, Joshua Delport, Tusekile S. Kangwa, Ziyaad Rahman, Ahmed A. Hussein, Dietrich E. Lorke, Okobi E. Ekpo
{"title":"An update on the bioactivities and health benefits of two plant-derived lignans, phyllanthin and hypophyllanthin","authors":"Sylvester I. Omoruyi, Joshua Delport, Tusekile S. Kangwa, Ziyaad Rahman, Ahmed A. Hussein, Dietrich E. Lorke, Okobi E. Ekpo","doi":"10.1007/s13596-023-00738-7","DOIUrl":null,"url":null,"abstract":"<div><p>Polyphenols are notable phytochemicals mostly found in plant-based foods, with many reported health benefits. Only limited information is available in the literature on polyphenolic lignans; hence, this review highlights the findings from an extensive open-ended search performed on many databases and search engines, using the keywords “phyllanthin” and “hypophyllanthin” inserted separately and jointly into these databases. Up to 2700 distinct articles were generated, most of which were related to plants of the <i>Phyllanthus</i> species. Plant extract-based articles were excluded. 468 original articles and bibliographic reviews that met the inclusion criteria were selected. Our search showed that both lignans were mostly isolated from plant sources, and some of their biological and pharmacological activities have been previously studied in in silico, in vitro and in vivo experimental models. Only a few human studies were reported, mainly in ex-vivo studies with blood samples and parasites. The antioxidant, anti-inflammatory and immunomodulatory, cardiovascular and cardioprotective, antimicrobial, antiviral, antiparasitic, neuroprotective and neuroactive, anti-diabetic, reno-protective and uricosuric, hepatoprotective, metabolic as well as anticancer effects are well-documented and described in the different sections of this review, as summarized in Table 1. No direct toxicity and side effects were reported. The health benefits identified in the reviewed articles potentially provide some rationale for further scientific research on these lignans’ toxicology, safety profiles, pharmacokinetics, and pharmacodynamics, with a view to progressing through the clinical trial phases of the drug discovery and development process.\n</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Traditional Medicine","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s13596-023-00738-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Polyphenols are notable phytochemicals mostly found in plant-based foods, with many reported health benefits. Only limited information is available in the literature on polyphenolic lignans; hence, this review highlights the findings from an extensive open-ended search performed on many databases and search engines, using the keywords “phyllanthin” and “hypophyllanthin” inserted separately and jointly into these databases. Up to 2700 distinct articles were generated, most of which were related to plants of the Phyllanthus species. Plant extract-based articles were excluded. 468 original articles and bibliographic reviews that met the inclusion criteria were selected. Our search showed that both lignans were mostly isolated from plant sources, and some of their biological and pharmacological activities have been previously studied in in silico, in vitro and in vivo experimental models. Only a few human studies were reported, mainly in ex-vivo studies with blood samples and parasites. The antioxidant, anti-inflammatory and immunomodulatory, cardiovascular and cardioprotective, antimicrobial, antiviral, antiparasitic, neuroprotective and neuroactive, anti-diabetic, reno-protective and uricosuric, hepatoprotective, metabolic as well as anticancer effects are well-documented and described in the different sections of this review, as summarized in Table 1. No direct toxicity and side effects were reported. The health benefits identified in the reviewed articles potentially provide some rationale for further scientific research on these lignans’ toxicology, safety profiles, pharmacokinetics, and pharmacodynamics, with a view to progressing through the clinical trial phases of the drug discovery and development process.
期刊介绍:
Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.