An update on the bioactivities and health benefits of two plant-derived lignans, phyllanthin and hypophyllanthin

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Advances in Traditional Medicine Pub Date : 2024-01-27 DOI:10.1007/s13596-023-00738-7
Sylvester I. Omoruyi, Joshua Delport, Tusekile S. Kangwa, Ziyaad Rahman, Ahmed A. Hussein, Dietrich E. Lorke, Okobi E. Ekpo
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Abstract

Polyphenols are notable phytochemicals mostly found in plant-based foods, with many reported health benefits. Only limited information is available in the literature on polyphenolic lignans; hence, this review highlights the findings from an extensive open-ended search performed on many databases and search engines, using the keywords “phyllanthin” and “hypophyllanthin” inserted separately and jointly into these databases. Up to 2700 distinct articles were generated, most of which were related to plants of the Phyllanthus species. Plant extract-based articles were excluded. 468 original articles and bibliographic reviews that met the inclusion criteria were selected. Our search showed that both lignans were mostly isolated from plant sources, and some of their biological and pharmacological activities have been previously studied in in silico, in vitro and in vivo experimental models. Only a few human studies were reported, mainly in ex-vivo studies with blood samples and parasites. The antioxidant, anti-inflammatory and immunomodulatory, cardiovascular and cardioprotective, antimicrobial, antiviral, antiparasitic, neuroprotective and neuroactive, anti-diabetic, reno-protective and uricosuric, hepatoprotective, metabolic as well as anticancer effects are well-documented and described in the different sections of this review, as summarized in Table 1. No direct toxicity and side effects were reported. The health benefits identified in the reviewed articles potentially provide some rationale for further scientific research on these lignans’ toxicology, safety profiles, pharmacokinetics, and pharmacodynamics, with a view to progressing through the clinical trial phases of the drug discovery and development process.

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两种植物源木脂素--叶黄素和次叶黄素的生物活性和健康益处的最新进展
多酚是一种显著的植物化学物质,大多存在于植物性食品中,据报道对健康有许多益处。有关多酚木脂素的文献资料非常有限;因此,本综述重点介绍了在许多数据库和搜索引擎中进行的广泛的开放式搜索的结果,搜索时使用了 "phyllanthin "和 "hypophyllanthin "这两个关键词,分别或共同插入这些数据库。共生成了多达 2700 篇不同的文章,其中大部分与叶黄素属植物有关。以植物提取物为基础的文章被排除在外。符合纳入标准的原创文章和书目综述共有 468 篇。我们的搜索结果表明,这两种木脂素大多是从植物中分离出来的,而且之前已经在硅学、体外和体内实验模型中对它们的一些生物和药理活性进行了研究。只有少数人类研究报告,主要是利用血液样本和寄生虫进行的体外研究。抗氧化、抗炎和免疫调节、心血管和心脏保护、抗菌、抗病毒、抗寄生虫、神经保护和神经活性、抗糖尿病、肾脏保护和排尿、肝脏保护、新陈代谢以及抗癌作用都有详细的记录,并在本综述的不同章节中进行了描述,如表 1 所概述。没有关于直接毒性和副作用的报道。综述文章中指出的对健康的益处可能为进一步对这些木酚素的毒理学、安全性、药动学和药效学进行科学研究提供了一些理论依据,以期在药物发现和开发过程的临床试验阶段取得进展。
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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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