Impact of sleep disruption on cognitive function in patients with post-acute sequelae of SARS-CoV-2 infection: Initial findings from a Neuro-COVID-19 clinic

K. Reid, Louis T Ingram, M. Jimenez, Z. Orban, Sabra M. Abbott, Daniela Grimaldi, Kristen L. Knutson, Phyllis C Zee, Igor Koralnik, Mathew B Maas
{"title":"Impact of sleep disruption on cognitive function in patients with post-acute sequelae of SARS-CoV-2 infection: Initial findings from a Neuro-COVID-19 clinic","authors":"K. Reid, Louis T Ingram, M. Jimenez, Z. Orban, Sabra M. Abbott, Daniela Grimaldi, Kristen L. Knutson, Phyllis C Zee, Igor Koralnik, Mathew B Maas","doi":"10.1093/sleepadvances/zpae002","DOIUrl":null,"url":null,"abstract":"\n \n \n Fatigue, brain fog and sleep disturbance are among the most common symptoms of post-acute sequelae of SARS-CoV-2 infection (PASC). We sought to determine the impact of sleep disruption on cognition and quality-of-life in patients with neurologic manifestations of PASC (Neuro-PASC).\n \n \n \n Thirty-nine patients were recruited from Neuro-COVID-19 clinic. Mean age was 48.1 years, 71.8% were female, and 82% were never hospitalized for COVID-19. Patients were evaluated via clinical assessment, quality-of-life measures in domains of cognitive function, fatigue, sleep disturbance, anxiety, and depression, NIH toolbox cognitive tests, and 7 days of wrist actigraphy.\n \n \n \n The median number of neurologic symptoms attributed to PASC was 6, with brain fog being the most common in 89.7%. Regarding non-neurologic symptoms, 94.9% complained of fatigue and 74.4% of insomnia. Patients reported significant impairment in all quality-of-life domains and performed worse in a task of attention compared to a normative US population. Actigraphy showed Neuro-PASC patients had lower sleep efficiency, longer sleep latency (both p<0.001) and later sleep midpoint (p=0.039) compared to 71 age-matched healthy controls with no PASC history. Self-reported cognitive symptoms correlated with severity of fatigue (p<0.001), anxiety (p=0.05), and depression (p<0.01). Objective evidence of sleep disruption measured by wakefulness after sleep onset, sleep efficiency and latency were associated with decreased performance in attention and processing speed.\n \n \n \n Prospective studies including larger populations of patients are needed to fully determine the interplay of sleep disruption on the cognitive function and quality of life of patients with PASC.\n","PeriodicalId":21861,"journal":{"name":"SLEEP Advances","volume":" 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"SLEEP Advances","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/sleepadvances/zpae002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Fatigue, brain fog and sleep disturbance are among the most common symptoms of post-acute sequelae of SARS-CoV-2 infection (PASC). We sought to determine the impact of sleep disruption on cognition and quality-of-life in patients with neurologic manifestations of PASC (Neuro-PASC). Thirty-nine patients were recruited from Neuro-COVID-19 clinic. Mean age was 48.1 years, 71.8% were female, and 82% were never hospitalized for COVID-19. Patients were evaluated via clinical assessment, quality-of-life measures in domains of cognitive function, fatigue, sleep disturbance, anxiety, and depression, NIH toolbox cognitive tests, and 7 days of wrist actigraphy. The median number of neurologic symptoms attributed to PASC was 6, with brain fog being the most common in 89.7%. Regarding non-neurologic symptoms, 94.9% complained of fatigue and 74.4% of insomnia. Patients reported significant impairment in all quality-of-life domains and performed worse in a task of attention compared to a normative US population. Actigraphy showed Neuro-PASC patients had lower sleep efficiency, longer sleep latency (both p<0.001) and later sleep midpoint (p=0.039) compared to 71 age-matched healthy controls with no PASC history. Self-reported cognitive symptoms correlated with severity of fatigue (p<0.001), anxiety (p=0.05), and depression (p<0.01). Objective evidence of sleep disruption measured by wakefulness after sleep onset, sleep efficiency and latency were associated with decreased performance in attention and processing speed. Prospective studies including larger populations of patients are needed to fully determine the interplay of sleep disruption on the cognitive function and quality of life of patients with PASC.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
睡眠中断对 SARS-CoV-2 感染后急性后遗症患者认知功能的影响:神经-COVID-19 诊所的初步发现
疲劳、脑雾和睡眠障碍是 SARS-CoV-2 感染(PASC)急性后遗症最常见的症状之一。我们试图确定睡眠障碍对有神经系统表现的 PASC(神经-PASC)患者的认知能力和生活质量的影响。 我们从 Neuro-COVID-19 诊所招募了 39 名患者。平均年龄为 48.1 岁,71.8% 为女性,82% 的患者从未因 COVID-19 住院治疗。患者通过临床评估、认知功能、疲劳、睡眠障碍、焦虑和抑郁领域的生活质量测量、美国国立卫生研究院工具箱认知测试以及 7 天腕部动图进行评估。 归因于 PASC 的神经系统症状的中位数为 6 个,其中 89.7% 的患者最常见的症状是脑雾。关于非神经系统症状,94.9% 的患者抱怨疲劳,74.4% 的患者抱怨失眠。与美国常模人群相比,患者在所有生活质量领域都有明显损害,在注意力任务中的表现更差。动图显示,与71名无PASC病史的年龄匹配健康对照组相比,神经-PASC患者的睡眠效率较低、睡眠潜伏期较长(均为p<0.001)、睡眠中点较晚(p=0.039)。自我报告的认知症状与疲劳(p<0.001)、焦虑(p=0.05)和抑郁(p<0.01)的严重程度相关。根据睡眠开始后的觉醒程度、睡眠效率和潜伏期来衡量睡眠中断的客观证据与注意力和处理速度的下降有关。 要全面确定睡眠障碍对 PASC 患者认知功能和生活质量的影响,还需要进行包括更多患者在内的前瞻性研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
A Central Role of Sulcal Width in the Associations of Sleep Duration and Depression with Cognition in Mid to Late Life Clinical and Financial Significance of Insomnia within a Large Payor-Provider Health System Impact of Real-World Implementation of Evidence-Based Insomnia Treatment within a Large Payor-Provider Health System: Initial Provider and Patient-Level Outcomes Poor Sleep and Inflammatory Gene Expression Among Care Partners of Persons Living with Dementia: A Pilot Trial of a Behavioral Sleep Intervention Sex-Specific Associations Between Habitual Snoring and Cancer Prevalence: Insights from a U.S. Cohort Study
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1