Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics: X Pub Date : 2024-01-23 DOI:10.1016/j.ijpx.2024.100231
Nilesh Rarokar , Sakshi Yadav , Suprit Saoji , Pratiksha Bramhe , Rishabh Agade , Shailendra Gurav , Pramod Khedekar , Vetriselvan Subramaniyan , Ling Shing Wong , Vinoth Kumarasamy
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Abstract

Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications.

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磁性纳米系统是定向输送和诊断应用的工具:当前挑战与最新进展
在过去二十年里,磁性纳米系统在各个领域得到了广泛应用,因此研究人员对其给予了更多关注。金属纳米材料的抗菌和杀菌特性使其成为生物医学应用中不可或缺的纳米系统。此外,由于磁性、光学和荧光特性,磁性纳米系统还可用于诊断和治疗。超顺磁性氧化铁纳米粒子(SPIONs)和量子点(QDs)是应用最广泛的磁性纳米系统,其制备过程非常简单。通过表面改性,研究人员最近一直致力于将二氧化硅、铜和金等金属与磁性纳米系统共轭。这种纳米系统的杂化改变了纳米材料的结构特征,有助于提高其靶向药物和基因递送的功效。金属与胶束、立方体、脂质体和聚合物纳米材料等各种纳米材料的杂化,因其纳米尺寸范围大、无毒、生物相容性好而越来越受到关注。此外,它们还具有良好的可注射性和更高的靶向能力,可在外部磁场的作用下在靶点积聚。本文详细讨论了磁性纳米系统的结构、特性、与生物系统的相互作用以及诊断应用。
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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
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