Enantioselective α-heterofunctionalization reactions of catalytically generated C1-Lewis base enolates

Magdalena Piringer , Lotte Stockhammer , Lukas Vogl , David Weinzierl , Paul Zebrowski , Mario Waser
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Abstract

Chiral Lewis base (LB) organocatalysis has emerged as a powerful covalent catalysis concept which allows for highly selective asymmetric C–C and C-heteroatom bond formations. Considering significant recent progress in the development of strategies to access α-heterofunctionalized carboxylic acid derivatives under chiral LB catalysis, we wish to summarize the most significant concepts and advances in this field within this mini review now.

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催化生成的 C1-路易斯碱烯醇的对映体选择性 α-heterofunctionalization 反应
手性路易斯碱(LB)有机催化已成为一种强大的共价催化概念,可实现高选择性的不对称 C-C 键和 C-杂原子键的形成。考虑到最近在手性路易斯碱催化下获得α-杂官能团化羧酸衍生物的策略开发方面取得的重大进展,我们希望在这篇小型综述中总结一下该领域最重要的概念和进展。
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来源期刊
Tetrahedron chem
Tetrahedron chem Organic Chemistry
CiteScore
3.60
自引率
0.00%
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0
审稿时长
27 days
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