Natural products as potential modulators of pro-inflammatory cytokines signalling in Alzheimer's disease

Vikas Yadav , Mythri C , Murali Kumarasamy
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Abstract

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the primary cause of dementia in the elderly population. Previous studies have suggested that numerous processes are involved in the development of AD, such as the accumulation of amyloid-β (Aβ) peptides, hyperphosphorylated tau (τ) proteins, and the pro-inflammatory cytokine signalling pathway, which results in neuroinflammation. Elevated microglial activation and the expression of cytokines, reactive oxygen species (ROS), and nuclear factor kappa B (NF-κB) also participate in the pro-inflammatory process of AD. Together, these processes contribute significantly to disease progression. To slow disease progression, this review focuses on pro-inflammatory cytokine signalling and the molecular mechanisms influenced by natural compounds. Natural products have many known beneficial health effects in neurodegenerative diseases, specifically because of their anti-inflammatory properties. Natural products are capable of decreasing symptoms and alleviating the development of several diseases, including AD, thus attracting the attention of the scientific community and the pharmaceutical industry. This review focuses on the therapeutic potential of abundant natural products and their bioactive compounds, which can modulate pro-inflammatory cytokine signalling in AD.

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天然产品作为阿尔茨海默病中促炎细胞因子信号的潜在调节剂
阿尔茨海默病(AD)是最常见的神经退行性疾病,也是导致老年人痴呆的主要原因。以往的研究表明,阿尔茨海默病的发病涉及多个过程,如淀粉样蛋白-β(Aβ)肽、高磷酸化 tau(τ)蛋白的积累,以及导致神经炎症的促炎细胞因子信号通路。小胶质细胞活化和细胞因子、活性氧(ROS)和核因子卡巴 B(NF-κB)表达的升高也参与了 AD 的促炎过程。这些过程共同对疾病的进展起着重要作用。为了减缓疾病的进展,本综述将重点关注促炎细胞因子信号传导以及受天然化合物影响的分子机制。天然产品对神经退行性疾病有许多已知的有益健康作用,特别是因为它们具有抗炎特性。天然产品能够减轻症状,缓解包括注意力缺失症在内的多种疾病的发展,因此吸引了科学界和制药业的关注。这篇综述重点探讨了丰富的天然产品及其生物活性化合物的治疗潜力,它们可以调节 AD 中的促炎细胞因子信号。
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