The effects of omega-3 fatty acid supplementation on serum myostatin, body composition, blood glucose, lipid profile and hs-CRP level in overweight men with coronary heart disease: A randomized double-blind placebo controlled clinical trial

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2024-01-28 DOI:10.1016/j.hnm.2024.200248
Mohammad sharifzadeh , Leila setayesh , Mohammad Reza Emami , Shirin Jafari Salim , Mo hammad Hassan Javanbakht
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Abstract

Background

Cardiovascular diseases, including heart cachexia, are considered as one of the most critical issues in health care that could be affected by several factors, such as myostatin whose critical role has been confirmed in the progress of heart cachexia and cardiac muscle dysfunction. This study was conducted to clarify the precise role of omega-3 polyunsaturated fatty acid (ω-3PUFA) on lipid profile, blood glucose, body composition, and serum level of myostatin in individuals with coronary artery disease (CAD).

Materials and methods

Forty-two adult males (aged 45–65 years) with CAD had been confirmed by angiography were randomly divided into two groups, group 1 received omega-3 (1200mg daily) and group 2 received placebo (paraffin) for 8 weeks. The serum level of myostatin was measured using an ELISA kit in the beginning and at the end of the intervention. Moreover, body composition and anthropometric measurements of the patients were also evaluated.

Result

A significant difference was observed in the myostatin level after 8weeks of intervention with omega3 supplement between omega3 and placebo group (p = 0.02).There was a significant difference in high-sensitivity C-reactive protein(hsCRP) concentration (p = 0.02) and low-density lipoprotein cholesterol (p = 0.01) between intervention group and control group at the end of the intervention. However, no statistically significant changes were seen in the body composition, anthropometric parameters, fasting insulin level, and fasting blood sugar within and between the groups.

Conclusion

Omega-3 oral supplementation may improve the status of CAD patients by decreasing the level of myostatin, LDL-C and hs-CRP.

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补充欧米伽-3 脂肪酸对患有冠心病的超重男性血清肌生成素、身体成分、血糖、血脂和 hs-CRP 水平的影响:随机双盲安慰剂对照临床试验
背景心血管疾病,包括心脏恶病质,被认为是医疗保健领域最关键的问题之一,它可能受到多种因素的影响,例如肌他汀,其在心脏恶病质和心肌功能障碍的进展中的关键作用已被证实。本研究旨在阐明欧米伽-3 多不饱和脂肪酸(ω-3PUFA)对冠状动脉疾病(CAD)患者的血脂、血糖、身体成分和血清肌生成素水平的确切作用。材料和方法将 42 名经血管造影证实患有 CAD 的成年男性(45-65 岁)随机分为两组,第一组接受欧米伽-3(每天 1200 毫克)治疗,第二组接受安慰剂(石蜡)治疗,为期 8 周。在干预开始和结束时,使用酶联免疫吸附试剂盒测定血清中肌生长激素的水平。干预结束时,干预组和对照组的高敏C反应蛋白(hsCRP)浓度(p = 0.02)和低密度脂蛋白胆固醇(p = 0.01)有显著差异。结论口服欧米伽-3补充剂可降低肌生成素、低密度脂蛋白胆固醇和hs-CRP的水平,从而改善CAD患者的状况。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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