Current approaches in nanostructured biomaterials in treatment of leiomyosarcoma

Abstract

One form of uncommon cancer that develops in the smooth muscles is called leiomyosarcoma, or LMS. The body's hollow organs, such as the stomach, bladder, intestines, and blood vessels, contain smooth muscles. The three main components of conventional therapy are surgery, chemotherapy, and radiotherapy. These treatments have numerous drawbacks, including insufficient surgical resection, drug resistance to chemotherapy, radiotherapy insensitivity, and postoperative bone defects. Because of their easy modification, targeting, and other characteristics, along with their unique physicochemical properties, nanoparticles have been used extensively in research on anti-leiomyosarcoma treatment. Inhibiting the onset and progression of leiomyosarcoma, nanoparticles can have a variety of effects on the growth of leiomyosarcoma cells. We provide a brief overview of the development of nanoparticle research closely associated with leiomyosarcoma treatment in this review.