Lipid raft disruption as an opportunity for peripheral analgesia

IF 4 3区 医学 Q1 PHARMACOLOGY & PHARMACY Current Opinion in Pharmacology Pub Date : 2024-01-30 DOI:10.1016/j.coph.2024.102432
Andrea Kinga Nehr-Majoros , Ágnes Király , Zsuzsanna Helyes , Éva Szőke
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Abstract

Chronic pain conditions are unmet medical needs, since the available drugs, opioids, non-steroidal anti-inflammatory/analgesic drugs and adjuvant analgesics do not provide satisfactory therapeutic effect in a great proportion of patients. Therefore, there is an urgent need to find novel targets and novel therapeutic approaches that differ from classical pharmacological receptor antagonism. Most ion channels and receptors involved in pain sensation and processing such as Transient Receptor Potential ion channels, opioid receptors, P2X purinoreceptors and neurokinin 1 receptor are located in the lipid raft regions of the plasma membrane. Targeting the membrane lipid composition and structure by sphingolipid or cholesterol depletion might open future perspectives for the therapy of chronic inflammatory, neuropathic or cancer pain, most importantly acting at the periphery.

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脂质筏破坏为外周镇痛提供了机会。
由于现有药物、阿片类药物、非甾体类消炎/镇痛药物和辅助镇痛药物无法为大部分患者提供令人满意的治疗效果,因此慢性疼痛是一种尚未得到满足的医疗需求。因此,迫切需要找到不同于传统药物受体拮抗的新靶点和新的治疗方法。大多数参与痛觉和疼痛处理的离子通道和受体,如瞬时受体电位离子通道、阿片受体、P2X 嘌呤受体和神经激肽 1 受体都位于质膜的脂质筏区域。通过消耗鞘脂或胆固醇来靶向膜脂组成和结构,可能会为治疗慢性炎症性疼痛、神经病理性疼痛或癌症疼痛开辟新的前景,其中最重要的是在外周发挥作用。
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来源期刊
CiteScore
8.80
自引率
2.50%
发文量
131
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.
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