Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

IF 8.6 2区 化学 Q1 Chemistry Topics in Current Chemistry Pub Date : 2024-01-31 DOI:10.1007/s41061-024-00451-2
Vipin K. Maikhuri, Divya Mathur, Ankita Chaudhary, Rajesh Kumar, Virinder S. Parmar, Brajendra K. Singh
{"title":"Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives","authors":"Vipin K. Maikhuri,&nbsp;Divya Mathur,&nbsp;Ankita Chaudhary,&nbsp;Rajesh Kumar,&nbsp;Virinder S. Parmar,&nbsp;Brajendra K. Singh","doi":"10.1007/s41061-024-00451-2","DOIUrl":null,"url":null,"abstract":"<div><p>Pyrimidine is a pharmacologically important moiety that exhibits diverse biological activities. This review reflects the growing significance of transition metal-catalyzed reactions for the synthesis of pyrimidines (with no discussion being made on the transition metal-catalyzed functionalization of pyrimidines). The effect of different catalysts on the selectivity/yields of pyrimidines and catalyst recyclability (wherever applicable) are described, together with attempts to illustrate the role of the catalyst through mechanisms. Although several methods have been researched for synthesizing this privileged scaffold, there has been a considerable push to expand transition metal-catalyzed, sustainable, efficient and selective synthetic strategies leading to pyrimidines. The aim of the authors with this update (2017–2023) is to drive the designing of new transition metal-mediated protocols for pyrimidine synthesis.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":802,"journal":{"name":"Topics in Current Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Topics in Current Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s41061-024-00451-2","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0

Abstract

Pyrimidine is a pharmacologically important moiety that exhibits diverse biological activities. This review reflects the growing significance of transition metal-catalyzed reactions for the synthesis of pyrimidines (with no discussion being made on the transition metal-catalyzed functionalization of pyrimidines). The effect of different catalysts on the selectivity/yields of pyrimidines and catalyst recyclability (wherever applicable) are described, together with attempts to illustrate the role of the catalyst through mechanisms. Although several methods have been researched for synthesizing this privileged scaffold, there has been a considerable push to expand transition metal-catalyzed, sustainable, efficient and selective synthetic strategies leading to pyrimidines. The aim of the authors with this update (2017–2023) is to drive the designing of new transition metal-mediated protocols for pyrimidine synthesis.

Graphical Abstract

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
过渡金属催化的嘧啶合成:最新进展、机理、范围和未来展望
嘧啶是一种具有重要药理作用的分子,具有多种生物活性。本综述反映了过渡金属催化反应在合成嘧啶方面日益重要的作用(没有讨论过渡金属催化的嘧啶官能化)。本文介绍了不同催化剂对嘧啶选择性/产率和催化剂可回收性(如适用)的影响,并试图通过机理说明催化剂的作用。尽管人们已经研究出多种合成这种特殊支架的方法,但仍在大力推广过渡金属催化的、可持续的、高效的和选择性的嘧啶合成策略。作者通过本次更新(2017-2023 年)的目的是推动设计新的过渡金属介导的嘧啶合成方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
期刊最新文献
Schiff Base-Based Molybdenum Complexes as Green Catalyst in the Epoxidation Reaction: A Minireview Recent Advances in the Synthesis of Acyclic Nucleosides and Their Therapeutic Applications The Benzoxazole Heterocycle: A Comprehensive Review of the Most Recent Medicinal Chemistry Developments of Antiproliferative, Brain-Penetrant, and Anti-inflammatory Agents Unveiling the Significance of tert-Butoxides in Transition Metal-Free Cross-Coupling Reactions Research Progress of Deep-Red to Near-Infrared Electroluminescent Materials Based on Organic Cyclometallated Platinum(II) Complexes
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1