Sarah Ewald, Azadeh Nasuhidehnavi, Tzu-Yu Feng, Mahbobeh Lesani, Laura-Isobel McCall
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引用次数: 0
Abstract
SUMMARYProtozoan parasite infection dramatically alters host metabolism, driven by immunological demand and parasite manipulation strategies. Immunometabolic checkpoints are often exploited by kinetoplastid and protozoan parasites to establish chronic infection, which can significantly impair host metabolic homeostasis. The recent growth of tools to analyze metabolism is expanding our understanding of these questions. Here, we review and contrast host metabolic alterations that occur in vivo during infection with Leishmania, trypanosomes, Toxoplasma, Plasmodium, and Cryptosporidium. Although genetically divergent, there are commonalities among these pathogens in terms of metabolic needs, induction of the type I immune responses required for clearance, and the potential for sustained host metabolic dysbiosis. Comparing these pathogens provides an opportunity to explore how transmission strategy, nutritional demand, and host cell and tissue tropism drive similarities and unique aspects in host response and infection outcome and to design new strategies to treat disease.
摘要原生动物寄生虫感染会极大地改变宿主的新陈代谢,这是由免疫需求和寄生虫操纵策略驱动的。免疫代谢检查点经常被奇异变形虫和原生动物寄生虫利用来建立慢性感染,从而严重损害宿主的代谢平衡。近年来,新陈代谢分析工具的发展扩大了我们对这些问题的理解。在这里,我们回顾并对比了宿主在体内感染利什曼原虫、锥虫、弓形虫、疟原虫和隐孢子虫时发生的代谢改变。虽然这些病原体在基因上存在差异,但它们在代谢需求、诱导清除病原体所需的 I 型免疫反应以及宿主持续代谢紊乱的可能性等方面存在共性。通过比较这些病原体,我们有机会探索传播策略、营养需求以及宿主细胞和组织滋养性是如何驱动宿主反应和感染结果的相似性和独特性,并设计出治疗疾病的新策略。
期刊介绍:
Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.