Rosae multiflorae fructus regulates the lipogenesis in high-fat diet-induced NAFLD mice model.

Physical activity and nutrition Pub Date : 2023-12-01 Epub Date: 2023-12-31 DOI:10.20463/pan.2023.0038

Kibong Kim, Hyun Joo Jang, Suji Baek, Sang-Hyun Ahn

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Abstract

Purpose: Exercise helps modify the lipid profile in the body, partly through its impact on sterol regulatory element binding protein-1 (SREBP-1) and peroxisome proliferator-activated receptor-γ (PPAR-γ). Individual differences in response to exercise and genetic variations may influence the response to PA. Therefore, this study explored Rosae multiflorae fructus (RMF) as a supplement candidate that improves exercise capacity and controls non-alcoholic fatty liver disease (NAFLD) by suppressing lipogenesis and controlling lipid peroxidation.

Methods: RMF is a natural herbal medicine used in Dongui Bogam. RMF has antioxidant, anti-inflammatory, and anti-allergic effects. However, the effects of RMF on NAFLD have not yet been investigated. In this study, we examined the effects of RMF in a mouse model of high-fat diet-induced NAFLD. Mouse livers were isolated and analyzed using H&E staining and immunohistochemistry.

Results: RMF downregulated lipid peroxidation markers, such as CYP2E1, in the livers of mice with high-fat diet-induced NAFLD. Additionally, the RMF significantly reduced the lipid accumulation-related protein expression of CD36, SREBP-1, and PPAR-γ.

Conclusion: RMF exerts anti-lipid peroxidation and anti-lipogenic effects in a high-fat diet-induced NAFLD mouse model.

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多花蔷薇果能调节高脂饮食诱导的非酒精性脂肪肝小鼠模型的脂肪生成。

目的：运动有助于改变体内的血脂状况，部分原因是运动会影响固醇调节元件结合蛋白-1（SREBP-1）和过氧化物酶体增殖激活受体-γ（PPAR-γ）。运动反应的个体差异和遗传变异可能会影响对 PA 的反应。因此，本研究将多花蔷薇果（RMF）作为一种候选补充剂，通过抑制脂肪生成和控制脂质过氧化来提高运动能力和控制非酒精性脂肪肝（NAFLD）：RMF是Dongui Bogam使用的一种天然草药。RMF具有抗氧化、抗炎和抗过敏作用。然而，尚未研究 RMF 对非酒精性脂肪肝的影响。在本研究中，我们研究了 RMF 对高脂饮食诱发的非酒精性脂肪肝小鼠模型的影响。小鼠肝脏被分离出来，并使用 H&E 染色法和免疫组织化学法进行分析：结果：RMF 下调了高脂饮食诱导的非酒精性脂肪肝小鼠肝脏中的脂质过氧化标记物，如 CYP2E1。此外，RMF 还能显著降低 CD36、SREBP-1 和 PPAR-γ 等脂质蓄积相关蛋白的表达：结论：在高脂饮食诱导的非酒精性脂肪肝小鼠模型中，RMF具有抗脂质过氧化和抗脂质生成的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physical activity and nutrition

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2.00

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