A lipoic acid supramolecular polymer-based hydrogel with self-regulating ROS, reduced blood sugar, and antibacterial ability for improved diabetic wound healing

IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Science: Advanced Materials and Devices Pub Date : 2024-02-01 DOI:10.1016/j.jsamd.2024.100677
Ling Wang , Guojuan Fan , Lijie Zhu , Yuzhong Zhang , Xiaoxia Wang , Jiamin Qin , Keliang Lu , Jinxing Hu , Jinlong Ma
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Abstract

Diabetic wound healing poses a significant challenge, and there is a growing need to develop a comprehensive treatment approach in this field of research. Recently, natural lipoic acid has garnered considerable attention because it can polymerize through dynamic disulfide bonds. Here, we developed an α-lipoic acid (LA) supramolecular polymer-based hydrogel (BI-AuLA) with gold nanostars (AuNSs), in which the bovine insulin (BI) improved diabetic wound healing. The LA supramolecular polymer plays a crucial role in restoring the damaged redox microenvironment by effectively regulating the balance between reactive oxygen species and glutathione. Additionally, the photothermal properties of AuNSs enable BI-AuLA to exhibit outstanding antibacterial activity against a range of bacteria when subjected to near-infrared (NIR) irradiation. Furthermore, BI-AuLA facilitates the sustained release of BI, thereby regulating local high glucose levels in the wound. Significantly, in the diabetes mellitus skin defect model, BI-AuLA induces intensive blood vessel formation and promotes uniform collagen arrangement, thereby facilitating effective wound healing. This groundbreaking supramolecular polymer-based hydrogel represents a highly embodied and tremendously encouraging strategy for addressing the challenges posed by extensive tissue damage resulting from diabetes.

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一种具有自我调节 ROS、降低血糖和抗菌能力的硫辛酸超分子聚合物基水凝胶,可改善糖尿病伤口愈合
糖尿病伤口愈合是一项重大挑战,在这一研究领域,人们越来越需要开发一种综合治疗方法。最近,天然硫辛酸因其可通过动态二硫键聚合而备受关注。在这里,我们开发了一种α-硫辛酸(LA)超分子聚合物水凝胶(BI-AuLA),其中含有金纳米柱(AuNSs),牛胰岛素(BI)可改善糖尿病伤口愈合。LA 超分子聚合物通过有效调节活性氧和谷胱甘肽之间的平衡,在恢复受损的氧化还原微环境方面发挥了重要作用。此外,AuNSs 的光热特性使 BI-AuLA 在近红外(NIR)照射下对一系列细菌具有出色的抗菌活性。此外,BI-AuLA 还能促进 BI 的持续释放,从而调节伤口局部的高血糖水平。值得注意的是,在糖尿病皮肤缺损模型中,BI-AuLA 能诱导密集血管的形成,促进胶原蛋白的均匀排列,从而促进伤口的有效愈合。这种开创性的超分子聚合物水凝胶是应对糖尿病造成的广泛组织损伤所带来的挑战的一种高度体现性的战略,令人鼓舞。
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来源期刊
Journal of Science: Advanced Materials and Devices
Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials
CiteScore
11.90
自引率
2.50%
发文量
88
审稿时长
47 days
期刊介绍: In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.
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