A lipoic acid supramolecular polymer-based hydrogel with self-regulating ROS, reduced blood sugar, and antibacterial ability for improved diabetic wound healing
Ling Wang , Guojuan Fan , Lijie Zhu , Yuzhong Zhang , Xiaoxia Wang , Jiamin Qin , Keliang Lu , Jinxing Hu , Jinlong Ma
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引用次数: 0
Abstract
Diabetic wound healing poses a significant challenge, and there is a growing need to develop a comprehensive treatment approach in this field of research. Recently, natural lipoic acid has garnered considerable attention because it can polymerize through dynamic disulfide bonds. Here, we developed an α-lipoic acid (LA) supramolecular polymer-based hydrogel (BI-AuLA) with gold nanostars (AuNSs), in which the bovine insulin (BI) improved diabetic wound healing. The LA supramolecular polymer plays a crucial role in restoring the damaged redox microenvironment by effectively regulating the balance between reactive oxygen species and glutathione. Additionally, the photothermal properties of AuNSs enable BI-AuLA to exhibit outstanding antibacterial activity against a range of bacteria when subjected to near-infrared (NIR) irradiation. Furthermore, BI-AuLA facilitates the sustained release of BI, thereby regulating local high glucose levels in the wound. Significantly, in the diabetes mellitus skin defect model, BI-AuLA induces intensive blood vessel formation and promotes uniform collagen arrangement, thereby facilitating effective wound healing. This groundbreaking supramolecular polymer-based hydrogel represents a highly embodied and tremendously encouraging strategy for addressing the challenges posed by extensive tissue damage resulting from diabetes.
期刊介绍:
In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research.
Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science.
With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.