Metagenomic Next-generation Sequencing for Pathogen Identification in Bronchoalveolar Lavage Fluid From Neonates Receiving Extracorporeal Membrane Oxygenation.

Yi-Rong Zheng, Xiu-Hua Chen, Qiang Chen, Hua Cao
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Abstract

Neonates on extracorporeal membrane oxygenation (ECMO) are at high risk of infection. Rapid and accurate identification of pathogens is essential to improve the prognosis of children on ECMO. Metagenome next-generation sequencing (mNGS) has been used in recent years to detect pathogenic bacteria, but evidence for its use in neonates on ECMO is lacking.
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元基因组下一代测序用于鉴定接受体外膜氧合的新生儿支气管肺泡灌洗液中的病原体。
接受体外膜氧合(ECMO)的新生儿感染风险很高。快速准确地识别病原体对改善 ECMO 患儿的预后至关重要。近年来,元基因组下一代测序(mNGS)已被用于检测致病菌,但其在使用 ECMO 的新生儿中的应用还缺乏证据。
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