Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

IF 4.1 2区化学 Q2 POLYMER SCIENCE Chinese Journal of Polymer Science Pub Date : 2024-01-25 DOI:10.1007/s10118-024-3081-0

Tatiana N. Nekrasova, Andrei I. Fischer, Natalia A. Nesterova, Anatoliy V. Dobrodumov, Anzhelika V. Garshinina, Olga D. Shuvaeva, Natalya V. Zakharova, Evgenii F. Panarin

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引用次数: 0

Abstract

Water-soluble copolymers of p-methacrylamidobenzoic acid (MABA) with neutral comonomers (N-vinylpyrrolidone (VP), N-methyl-N-vinylacetamide (MVAA), N-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb³⁺ ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb³⁺ complexes with the copolymers was revealed. The luminescence intensity of Tb³⁺ complexes with the copolymers containing N-vinylamide units (VP, MVAA) is three times more intense than that observed for the complexes between Tb³⁺ and MAG-containing copolymers. In the case of NaSS-containing copolymers, the luminescence intensity is controlled by the values of binding constants between Tb³⁺ and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb³⁺ have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

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设计具有生物活性的大分子配体及其与铽离子的发光复合物

通过自由基共聚法合成了对甲基丙烯酰胺基苯甲酸（MABA）与中性共聚单体（N-乙烯基吡咯烷酮（VP）、N-甲基-N-乙烯基乙酰胺（MVAA）、N-甲基丙烯酰氨基葡萄糖（MAG））和阴离子共聚单体苯乙烯磺酸钠（NaSS）的水溶性共聚物。研究了所制备的共聚物与 Tb3+ 离子在水溶液中的相互作用；发现共聚单体的化学结构对 Tb3+ 与共聚物复合物的发光强度有显著影响。Tb3+ 与含有 N-乙烯酰胺单元（VP、MVAA）的共聚物的配合物的发光强度是 Tb3+ 与含有 MAG 的共聚物配合物发光强度的三倍。对于含 NaSS 的共聚物，发光强度受 Tb3+ 和 MABA 之间的结合常数值以及共聚物中 MABA 单元的含量控制。所研究的共聚物及其与 Tb3+ 的复合物对人类呼吸道合胞病毒具有较低的细胞毒性和明显的抗病毒活性。

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来源期刊

Chinese Journal of Polymer Science 化学-高分子科学

CiteScore

7.10

自引率

11.60%

发文量

218

审稿时长

6.0 months

期刊介绍： Chinese Journal of Polymer Science (CJPS) is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry, Chinese Academy of Sciences. CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included. The journal was first published in 1983 under the title Polymer Communications and has the current name since 1985. CJPS is a peer-reviewed journal dedicated to the timely publication of original research ideas and results in the field of polymer science. The issues may carry regular papers, rapid communications and notes as well as feature articles. As a leading polymer journal in China published in English, CJPS reflects the new achievements obtained in various laboratories of China, CJPS also includes papers submitted by scientists of different countries and regions outside of China, reflecting the international nature of the journal.