Chemistry and biology of marine-derived Trichoderma metabolites

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-02-02 DOI:10.1007/s13659-024-00433-3

Yin-Ping Song, Nai-Yun Ji

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Abstract

Marine-derived fungi of the genus Trichoderma have been surveyed for pharmaceuticals and agrochemicals since 1993, with various new secondary metabolites being characterized from the strains of marine animal, plant, sediment, and water origin. Chemical structures and biological activities of these metabolites are comprehensively reviewed herein up to the end of 2022 (covering 30 years). More than 70 strains that belong to at least 18 known Trichoderma species have been chemically investigated during this period. As a result, 445 new metabolites, including terpenes, steroids, polyketides, peptides, alkaloids, and others, have been identified, with over a half possessing antimicroalgal, zooplankton-toxic, antibacterial, antifungal, cytotoxic, anti-inflammatory, and other activities. The research is highlighted by the molecular diversity and antimicroalgal potency of terpenes and steroids. In addition, metabolic relevance along with co-culture induction in the production of new compounds is also concluded. Trichoderma strains of marine origin can transform and degrade heterogeneous molecules, but these functions need further exploration.

Graphical Abstract

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海洋源毛霉代谢物的化学和生物学特性

摘要自 1993 年以来，对毛霉属海洋源真菌进行了药物和农用化学品调查，从海洋动物、植物、沉积物和水源菌株中鉴定出了各种新的次级代谢物。本文全面综述了截至 2022 年底（历时 30 年）这些代谢物的化学结构和生物活性。在此期间，对属于至少 18 个已知毛霉菌种的 70 多个菌株进行了化学研究。结果发现了 445 种新的代谢物，包括萜烯类、甾体类、多酮类、肽类、生物碱类等，其中一半以上具有抗微生物藻类、浮游动物毒性、抗菌、抗真菌、细胞毒性、抗炎等活性。萜类和甾类化合物的分子多样性和抗微生物藻类的效力是这项研究的亮点。此外，还总结了新化合物生产过程中的代谢相关性以及共培养诱导。海洋来源的毛霉菌株可以转化和降解异质分子，但这些功能还需要进一步探索。图表摘要

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.